白介素在哮喘与慢性支气管炎气道粘膜细胞的表达  

Expression of interleukin on airway mucosa cells of asthma and chronic bronchitis

作　　者：张蔚[1] 梁瑛[1] 刘从容[2] 姚天樵[1] 张慧信[1] 许翔[1] 高冬霞[2] 廖松林[2] 

机构地区：[1]首都医科大学附属北京安贞医院呼吸科,邮政编码100029 [2]北京医科大学病理研究室

出　　处：《北京医学》2001年第1期11-12,共2页Beijing Medical Journal

基　　金：北京市青年科干局基金资助

摘　　要：目的　探讨哮喘与慢性支气管炎 (慢支 )气道炎症性质的异同。方法　应用免疫组化技术 ,检测两组患者大气道粘膜嗜酸粒细胞阳离子蛋白特异性抗体 (EG1)、肿瘤坏死因子 (TNFα)、IL - 5、IL - 8的阳性细胞。结果　EG1、IL - 5阳性细胞数表达在哮喘组明显增高 ,IL - 8阳性细胞数表达在慢支组明显增高。结论　嗜酸性粒细胞活化及 IL - 5表达水平增高是哮喘性炎症的特点 ,而 IL - 8表达水平增高是慢支气道炎症的特点。Objective To explore the difference between the airway inflammatory features of asthma and chronic bronchitis.Methods By immunohistochemistry,to investigate positive cells of eosinophil cationic protein antibody 1 (EG1),tumor necrosis factor α (TNFα),interleulin 5(IL 5), 8(IL 8) in airway mucosa biopsie slides of asthma and chronic bronchitis.Results The number of EG1 and IL 5 positive cells increased significantly in asthma and the number of IL 8 positive cells increased significantly in chornic bronchitis.Conclusions Eosinphils activation and the increase of IL 5 expression is the feature of astham inflammation;the increase of IL 8 expression is the feature of chronic bronchitis airway inflammation.

关 键 词：哮喘 慢性支气管炎 白细胞介素 气道粘膜细胞 表达 

分 类 号：R562.25[医药卫生—呼吸系统] R562.21[医药卫生—内科学]