去白细胞全血输注在肾移植中的应用  

Transfusion of leukocyte-depleted blood in renal transplantation

作　　者：何强[1] 陈江华[1] 王逸民[1] 吴建永[1] 王苏娅[1] 朱俊[2] 张晓琛[2] 李之江[2] 

机构地区：[1]浙江大学医学院附属第一医院肾移植血液净化中心,杭州310003 [2]浙江大学医学院附属第一医院输血科,杭州310003

出　　处：《中华泌尿外科杂志》2001年第2期81-83,共3页Chinese Journal of Urology

摘　　要：目的　评价去白细胞全血输注法治疗肾移植前后高危贫血病人的临床价值。　方法　观察比较 15例肾移植前 (A组 )和 38例肾移植后 (B组 )病人输注去白细胞全血以及 33例肾移植前随机输血病人 (C组 )的群体反应抗体水平 (PRA)、急性排斥发生率和巨细胞病毒感染率及巨细胞病毒肺炎发生率。　结果　白细胞滤器的去白细胞效率为 (98.2± 1.5 ) % ,输注去白细胞全血病人仅 1例出现荨麻疹 ,A组输去白细胞全血后PRA阴性 ,肾移植术后无急性排斥发生 ,B组输血后无加重或发生排斥反应 ,C组术前PRA阳性率达 10 0 .0 % ,术后早期急性排斥率为 2 9.0 % ,A组与C组术后巨细胞病毒感染率及巨细胞病毒肺炎发生率差别无显著性意义。　结论　肾移植前后严重贫血短期无法纠正时 ,输注去白细胞全血是安全的。Objective To evaluate transfusing of leukocyte depleted blood to severe anemia patients before and after renal transplantation. Methods The efficiency of leukocyte removal filter was observed and the level of panel reactive antibody (PRA) compared.The acute rejection rate and the incidence of cytomegalovirus infection were studied in 53 leukocyte depleted blood transfused patients and in 33 whole blood transfused patients. Results The leukocyte removal rate of the filter reached 98.2%±1.5%.In the leukocyte depleted blood transfused patients,there was no rise of PRA neither the occurrence of acute rejection.Whereas the incidence of cytomegalovirus infection has been similar to those with whole blood transfusion.The whole blood transfused patients had high PRA and the early acute rejection rate reached 29.0% Conclusions The clinical application of leukocyte depleted blood transfusion for severe anemia patients before or after renal transfusion is safe and beneficial.

关 键 词：肾移植 输血 白细胞除去法 去白细胞全血输注法 

分 类 号：R699.2[医药卫生—泌尿科学] R457.1[医药卫生—外科学]