低强度华法林抗凝治疗75岁以上房颤患者疗效与安全性观察  

Efficacy and safety of low intensity warfarin on atrial fibrillation in elderly patients

作　　者：李晓丽 曹顺华 张晓霞 王东春 

机构地区：[1]唐山市工人医院老年医学科,河北省唐山市063000

出　　处：《实用老年医学》2014年第4期296-298,共3页Practical Geriatrics

摘　　要：目的观察低强度华法林治疗≥75岁房颤患者的有效性和安全性。方法150例≥75岁房颤患者随机分为华法林组（n=82）和阿司匹林组（n=68），华法林组接受低强度华法林抗凝治疗，将国际标准化比值（INR）控制在1．6～2．0；阿司匹林组接受阿司匹林（100mg／d）抗血小板治疗。观察2组患者1年内血栓栓塞事件和出血等不良反应发生率。结果华法林组血栓栓塞发生率为4．9％，阿司匹林组血栓栓塞发生率为14．7％，2组比较差异有统计学意义（P〈0．05）。华法林组出血发生率为6．1％，阿司匹林组出血发生率为5．9％，均为轻度出血，2组比较无统计学差异（P〉0．05）。结论应用低强度华法林抗凝治疗可明显降低老年房颤患者血栓栓塞事件发生率，且安全性好。Objective To identify the efficacy and safety of low intensity anticoagulation therapy by warfarin on atrial fibrillation in elderly patients. Methods 150 elderly patients aged 75 and over with atrial fibrillation were randomly divided into warfarin group （n = 82） and aspirin group （n = 68）. Warfarin group received low intensity anticoagulation ther- apy by warfarin （INR 1.6-2. 0）, and aspirin group received antiplatelet therapy by aspirin （ 100 rag/d）. The incidence of adverse reactions such as embolism and hemorrhage was observed within 1 year. Results The incidence of thromboem- bolic events was 4. 9% and 14. 7% in warfarin and aspirin group respectively. There was significant difference between the two groups （P〈0. 05）. Incidence of bleeding events in warfarin group was 6. 1%, compared with 5.9% in aspirin group. Only mild bleeding was observed in two groups. There was no significant difference between the two groups （P〉0. 05）. Conclusions Low intensity anticoagulation therapy by warfarin is safe and can obviously reduce the incidence of thrombo- embolic events in elderly patients with atrial fibrillation.

关 键 词：房颤 高龄 华法林 低强度抗凝治疗 

分 类 号：R541.75[医药卫生—心血管疾病]