先天性白内障大鼠血液生化及血液流变学分析  

Analysis of the routine blood counts and blood biochemical parameters and hemorheology in the rats with congenital cataract

作　　者：田小芸[1] 尤金炜[1] 董敏[1] 许龙祥[1] 赵志刚[1] 陈莉[1] 恽时锋[1] 

机构地区：[1]南京军区南京总医院比较医学科,南京210002

出　　处：《中国比较医学杂志》2014年第3期20-24,共5页Chinese Journal of Comparative Medicine

基　　金：南京总医院基金(2011001)

摘　　要：目的：测定先天性白内障大鼠血液常规、生化正常值及血液流变学变化。方法采用XS-800i血常规分析仪和OLYMPUS AV2700生化自动分析仪对185～211 g大鼠共计90只进行血液常规和生化检测及用SA-6600自动血流变测试仪对血液进行流变学的测定。结果血像检测结果是白内障与正常对照同性比较无差异显著性（P ＞0.05）；小眼白内障与正常对照同性比较红细胞宽度（RDW）间差异显著（P ＜0.01或 P ＜0.05）。血生化检测结果是白内障大鼠与正常对照组同性间比较白蛋白（ALB）差异显著（P ＜0.01或P ＜0.05）雌性与对照组比较尿素（Ure）差异显著（P ＜0.01），小眼白内障雌性与正常对照比较肌酐（Cr）差异非常显著（P ＜0.01）。白内障、小眼白内障大鼠的红细胞是雄性的低于雌性（P ＜0.05，P ＜0.01）而血小板是雄性的高于雌性（P ＜0.01），肌酐是雄性低于雌性P ＜0.01），正常组雄雌间无差异；血液流变学各组间无差异显著性。结论白内障大鼠与正常组大鼠间某些血常规及生化指标有一定的差异，该数据为该鼠在这领域的使用提供参考。Objective To measure the range of routine blood counts and blood biochemical parameters ,to analyze hemorheology of the rats with congenital cataract .Methods Blood samples were taken from 90 rats with congenital cataract weight about 185 ~211 g.Routine blood analysis was performed and blood biochemical and hemorheology paramenters were determind using an automatic blood biochemical and hemorheology analyzer .Results There were no significant difference （ P ＆gt;0.05 ） between the cataract rats and the normal rats in Blood test results; but there were significant difference between the microphthalmos cataract rats and the normal same -sex rats （ P 〈0.01 or P 〈0.05 ） . The biochemical results is the cataract rats and the normal rats were different significantly in ALB group （ P 〈0.01 or P＆lt;0.05）, and the female microphthalmos cataract rats compared with the control rats had significant difference in Ure （P＆lt;0.01） , the female cataract rats ompared with the normal rats were very significant difference in Cr group （ P 〈0.05 or P 〈0.01）.The erythrocyte counts of the male cataract rats and male microphthalmos cataract rats were significantly lower than that in the female ones, respectively（P 〈0.05, P 〈0.01）.The platelet counts of the male cataract rats and the male microphthalmos cataract rats were significantly higher than that in the female ones , respectively（P 〈0.01）, and the＆amp;nbsp;creatinine of the male cataract rats and the male microphthalmos cataract rats were significantly lower then that in the female ones, respectively（P 〈0.01）.There were no significant difference in every group on hemorheology .Conclusions There were significant differences in some blood indexes between the congenital cataract rats and the normal rats .These data may become useful reference for biomedical researcher in this field .

关 键 词：先天性白内障 大鼠 血常规 血生化 血液流变学 

分 类 号：R319[医药卫生—基础医学] R332