斯氏花群海葵多糖对大白鼠血压和兔离体心脏灌流的影响  

THE EFFECTS OF THE POLYSACCHARIDES FROM SEA ANEMONE ZOANTHUS STEPHENSONI ON PERFUSED ISOLATED RABBIT HEART TISSUE AND BLOOD PERSSURE OF RATS

作　　者：郑淑贞[1] 黄方吕[1] 潘亮君 龚克晖 郭澄联[2] 

机构地区：[1]中国科学院广州化学研究所 [2]中国科学院南海海洋研究所

出　　处：《广州化学》1991年第4期53-57,共5页Guangzhou Chemistry

基　　金：国家自然科学基金

摘　　要：斯氏花群海葵多糖Ⅰ和Ⅱ是从生长于我国南海西沙群岛的斯氏花群海葵(Zoanthus stephensoni)中分离提取得到的生理活性物质,它们对大白鼠的血压和兔离体心脏的灌流均有显著影响。多糖Ⅰ能使离体兔心脏的冠脉流量显著减少,心脏收缩力增强;而多糖Ⅱ则能使离体兔心脏冠脉流量显著增加,心脏收缩力显著增强。多糖Ⅰ和Ⅱ都能使大白鼠产生显著的降血压效应。Polysaccharide Ⅰ and Ⅱ were isolated from sea anemone Zoanthus stephensoni which lives in the Xisha Islands. In perfused isolated rabbit heart tissue, polysaccharide Ⅰ caused diminution of blood flow volume of the coronary artery and increase of myocardial contraction, but polysaccharide Ⅱ caused obviously increase of blood flow volume and myocardial contraction. Both polysaccharide Ⅰ and Ⅱ caused a marked hypotensive effect on the anesthetized rats.

关 键 词：斯氏花群海葵 多糖 心血管药 

分 类 号：R931.77[医药卫生—生药学]