济南城镇居民维生素D水平及分布  

Serum 25-hydroxyvitamin D status of urban residents in Jinan

作　　者：康东红[1] 郭涛[1] 王燕[1] 张洪美[1] 冯潇雨[1] 

机构地区：[1]山东大学附属千佛山医院内分泌科,250014

出　　处：《中华老年医学杂志》2014年第4期429-432,共4页Chinese Journal of Geriatrics

基　　金：山东省自然科学基金项目（2004ZX07）;民政部老年学和老年医学”十一五研究计划”（民人教科字[2008]47-1）

摘　　要：目的探讨济南城镇居民维生素D的营养状况，为防治与维生素D不足有关的慢性疾病提供依据。方法在本院所管辖的3个医疗保健社区分层随机抽取受检者1478例，年龄30～90岁，平均（58．4±13．O）岁；其中男性602例，平均年龄（59．8±13．O）岁；女性876例，平均年龄（57．4±12．9）岁；按10岁间隔年龄段分组。用酶联免疫吸附法（ELISA）测定血25羟维生素DC25（OH）D]水平。维生素D水平分布的界定：C25（0H）D3≥75．0nmol／L为维生素D营养充足，50．0～74．9nmol／L为临界，25．0～49．9nmol／L为不足，〈25．0nmol／L为缺乏。应用SPSS13．0软件进行统计分析。结果（1）男性C25（OH）D]水平58．6nmol／L（95％CI：56．7～60．5nmol／L），女性54．2nmol／L（95％CI：52．8～55．8nmol／L），均低于75nmol／L；70～79岁女性（25（OH）D]为49．1nmol／L（95％CI：45．7～52．5nmol／L）；80～90岁为41．7nmol／L（95％CI：38．2～46．7nmol／L），低于50nmol／L；（2）维生素D缺乏、不足、临界和充足，男性分别为5．6％、33．4％、36．5％和24．4％，女性分别为6．5％、42．9％、32．6％和18．1％；维生素D缺乏及不足发生率随年龄的增长而上升（男性：χ2=33．68，P=0．004；女性：χ2=55．7，P〈0．001）；60岁以上女性维生素D缺乏及不足较男性高，差异有统计学意义（60～69岁：χ2=9．387，P=0．025；80～90岁：χ2=8．896，P=0．031）；（3）C25（OH）D3水平以冬季最低C48．8nmol／L（95％CI：46．8～50．9nmol／L）]，秋季最高C60．2nmol／L（95％CI：58．0～62．3nmol／L）]；维生素D缺乏及不足发生率以冬季最高为7．6％及46．2％，秋季最低为5．5％及29．0％，差异有统计学意义（χ2=18．36，P=0．031）。结论城镇居民普遍存在维生素D缺乏及不足，以老年人群及其女性较为严重。血（25（OH）D3水平及分布与季节变化有关�Objective To explore the vitamin D nutritional status of urban residents in Jinan, in order to provide the basis for the prevention and treatment of chronic diseases associated with vitamin D insufficiency. Methods 1478 cases aged 30-90 years, including 602 men （59.84-13.0） years on average and 876 women （57.44-12.9） years on average were selected by a stratified random sampling from 3 community medical care institutions in Jinan. Subjects were divided into six groups according to the 10-year interval. Serum 25-hydroxyvitamin D [25 （OH） D] level was measured by enzyme-linked immunosorbent assay （ELISA）. Serum [25 （OH） D] level ≥ 75 nmol/L was defined as vitamin D sufficient, （50.0 - 74.9） nmol/L as vitamin D critical value, 25.0H 49.9 nmol/L as vitamin D insufficiency, 〈 25 nmol/L as vitamin D deficiency. All data processing and statistical analysis were finished by SPSS 13.0. Results The average level of [25 （OH） D] was 58.60 nmol/L in males （95% CI： 56.7- 60.5 nmol/L] and 54.17 nmol/L in females [95% CI： 52.8- 55.8 nmol/L], which were less than 75 nmol/L The average level of [25（OH） D] was 49. lnmol/L in females aged70-79 years （95%CI：45.7-52.5 nmol/L）, 41.7 nmol/L in females aged 80-90 years （95%CI：38.2 -46.7 nmol/L）, which were less than 50 nmol/L. The percentage of cases with vitamin D deficiency, insufficiency, critical value, and sufficiency was 5.6%, 33.4%, 36.5%, 24.4% in males, and 6.5%, 42.9%, 32.6%, 18. 1% in female respectively. The incidence of vitamin D deficiency and insufficiency was increased with ageing （male：）χ2= 33.68 P〈0.01, female：χ2= 55.7, P%0. 001）. The percentage of vitamin D deficiency and insufficiency was more in females than in males （60-69 years old： χ2=9.387, P〈0.05, 80-90 years old： χ2=8.896, P〈0.05）. The [25 （OH） D] level was lowest in winter （48.8 nmol/L, 95% CI：46.8-50.9 nmol/L） and highest in autumn （60.2 nmol/L, 95G CI： 58.0- 62.3 nmol/L）. The incidence of vitamin D deficiency an

关 键 词：维生素D缺乏 

分 类 号：R591.4[医药卫生—内科学]