Assessment of urinary concentration of cotinine in Chinese pregnant women exposed to environmental tobacco smoke  

作　　者：Yajing Lei Wenhui Liu Lizheng Fang Muhammad Sajid Hamid Akash Kanwal Rehman Hua Narenmandura Weixing Shi Weixian Lu Yingchun Xu Shuqing Chen 

机构地区：[1]Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University [2]Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University [3]College of Pharmacy, Government College University Faisalabad [4]Institute of Public Health, College of Medical Science, Zhejiang University [5]Hangzhou EPIE Bio-detection Technology Limited

出　　处：《Chinese Science Bulletin》2014年第13期1386-1391,共6页

基　　金：supported by Major Science and Technology Projects and Special Priority Themes of Zhejiang Province of China(2010C13030)

摘　　要：Environmental tobacco smoke(ETS)is a wellknown reason of many adverse health consequences in pregnant women.Exposure of ETS during pregnancy may increase the risk of some fetal diseases in pregnant women and/or birth defects in neonates.Many countries have implemented laws to control smoking and free of second hand smoke in all enclosed workplaces.In China,antismoking law was enforced in March 2010.We aimed to assess the exposure of pregnant women to cotinine after anti-smoking law was implemented in China.The urine samples were collected from 2,100 volunteers from Zhejiang Province,China and urinary concentration of cotinine was measured using gas chromatography and mass spectrometry.Cotinine was detected in 87%of the pregnant women.The GM and 95th percentile concentration inpregnant women were 4.28 and 44.00 lg/L,respectively.Similarly,the GM and 95th concentration of cotinine were significantly higher in smoking group than in non-smoking group(P\0.0001).Our results indicate that pregnant women in China are at the high risk of exposure ETS.Further attempts are required to make strategies to find out the sources of ETS exposure and prevent smoking at public places especially during pregnancy.Environmental tobacco smoke （ETS） is a well- known reason of many adverse health consequences in pregnant women. Exposure of ETS during pregnancy may increase the risk of some fetal diseases in pregnant women and/or birth defects in neonates. Many countries have implemented laws to control smoking and free of second hand smoke in all enclosed workplaces. In China, anti- smoking law was enforced in March 2010. We aimed to assess the exposure of pregnant women to cotinine after anti-smoking law was implemented in China. The urine samples were collected from 2,100 volunteers from Zhejiang Province, China and urinary concentration of cotinine was measured using gas chromatography and mass spectrometry. Cotinine was detected in 87 % of the pregnant women. The GM and 95th percentile concentration in pregnant women were 4.28 and 44.00 μg/L, respectively. Similarly, the GM and 95th concentration of cotinine were significantly higher in smoking group than in non-smoking group （P 〈 0.0001）. Our results indicate that pregnant women in China are at the high risk of exposure ETS. Further attempts are required to make strategies to find out the sources of ETS exposure and prevent smoking at public places especially during pregnancy.

关 键 词：烟雾浓度 烟草烟雾 孕妇 中国 尿液 评估 环境 怀孕期间 

分 类 号：R114[医药卫生—卫生毒理学]