薤白提取物对心肌缺氧缺血及缺血再灌注心肌损伤的保护作用  

Effects of the extract of Bulbus Allii macrostemi on hypoxia and myocardial ischemia and reperfusion

作　　者：吴波[1] 陈思维[2] 曹虹[2] 王敏伟[2] 

机构地区：[1]中国医科大学第一临床学院急诊科,辽宁沈阳110001 [2]沈阳药科大学药学系,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2001年第2期131-133,共3页Journal of Shenyang Pharmaceutical University

摘　　要：采用异丙肾上腺素致小鼠常压缺氧模型、垂体后叶素致大鼠急性心肌缺血模型及大鼠心肌缺血再灌注模型 ,考察薤白提取物抗心肌缺氧缺血及缺血后再灌注损伤的保护作用。结果表明薤白提取物能延长异丙肾上腺素作用的小鼠常压缺氧存活时间 ,对抗垂体后叶素所致的大鼠急性心肌缺血作用 。Effects of the extract of Bulbus Allii macrostemi(EA)on hypoxia and myocardial ischemia and reperfusion injury were studied.The model of normobaric hypoxia by isoprenaline and myocardial ischemia induced by pituiturin and reperfusion injury was adopted.EA prolonged the survival time of mice with isoprenaline in normobaric hyoxia,and protected rats against myocardial ischemia induced by pituitrin.Myocardial ischemica and reperfusion injury were mitigated by EA.

关 键 词：薤白 缺血 缺氧 再灌注损伤 

分 类 号：R542.2[医药卫生—心血管疾病]