阿托伐他汀钙口腔崩解片的制备工艺研究及含量控制  

Preparation process and content control of atorvastatin calcium oral disintegrating tablets

作　　者：张友智[1] 崔颖[1] 杨晓艳[1] 

机构地区：[1]武汉科技大学附属天佑医院,武汉430064

出　　处：《中南药学》2014年第1期25-28,共4页Central South Pharmacy

摘　　要：目的制备阿托伐他汀钙口腔崩解片,并评价其质量。方法采用正交设计方法优选出制备的最佳条件,以微晶纤维素、交联聚维酮为崩解剂,制备阿托伐他汀钙口腔崩解片。利用高效液相色谱法测定崩解片中阿托伐他汀钙的含量。结果阿托伐他汀钙口腔崩解片崩解时间在30 s内,含量稳定。结论该制备工艺简单易行,可用于阿托伐他汀钙口腔崩解片的制备及质量控制。Objective To prepare oral disintegrating tablets of atorvastatin calcium and assess its quality. Methods The conditions for preparation were optimized by orthogonal design. The microcrystalline cellulose and crosslinked polyvinylpyrrolidone were used as disintegrants to prepare atorvastatin calcium oral disintegrating tablets, and the content of atorvastatin calcium was determined by HPLC. Results The disintegration time of tablets of atorvastatin calcium was within 30 s, and the content was steady. Conclusion The preparation process is simple and feasible, which can be used for the preparation and quality control of atorvastatin calcium oral disintegrating tablets.

关 键 词：口腔崩解片 阿托伐他汀钙 制备工艺 崩解时限 

分 类 号：R944[医药卫生—药剂学] R917[医药卫生—药学]