苦物质引起去甲肾上腺素预收缩的大鼠主动脉平滑肌舒张的作用机理研究  

Relaxation Mechanism of Bitter Tastants on Rat Thoracic Aorta Precontracted by Norepinephrine

作　　者：刘庆华[1] 赛文博 于孟飞[1] 谈丽[1] 

机构地区：[1]中南民族大学 生命科学学院 湖北省武陵山区资源植物种质改良与利用重点实验室,武汉430074

出　　处：《中南民族大学学报（自然科学版）》2014年第1期23-27,共5页Journal of South-Central University for Nationalities：Natural Science Edition

基　　金：国家自然科学基金资助项目(31140087;30971514);国家"973"重大研究计划(2011CB809104)资助项目

摘　　要：为研究苦物质舒张预收缩的大鼠胸主动脉平滑肌的作用机制,以测定肌张力为主要手段,结合多种细胞信号通路阻断剂研究了苦物质的作用通路.结果表明:苦物质对于去甲肾上腺素介导的大鼠胸主动脉的收缩具有高效、快速的舒张作用,此舒张作用与IP3受体和L型钙通道的阻断密切相关.故以氯喹和苦精为代表的苦物质因对血管平滑肌具有良好的舒张作用,有望成为针对高血压等血管相关疾病的新的治疗药物.To elucidate the relaxation mechanism of bitter tastant on precontracted rat thoracic aorta , the effect of bitter tastants on muscle tension in rat thoracic aorta was investigated , combined with the application of a variety of cell signaling pathway blockers .The results indicated that bitter tastants induced an effective and fast relaxation of rat thoracic aorta precontracted by norepinephrine , which was closely related to the blocking of IP 3 receptor and L-type calcium channels . Thus bitter tastants represented by chloroquine and denatonium had good diastolic effect on vascular smooth muscle and had the potential to be used for blood vessel related diseases such as hypertension .

关 键 词：苦物质 大鼠胸主动脉 舒张 氯喹 IP3受体 L型钙通道 

分 类 号：R966[医药卫生—药理学]