氧氟沙星分子印迹聚合物的合成及优化  

Synthesis and optimization molecularly imprinted polymers of ofloxacin

作　　者：卜忐忐 宋立新 何娟[1] 胡碧玮 朱贝贝[1] 

机构地区：[1]河南工业大学化学化工学院,河南郑州450001 [2]河南水利与环境职业学院,河南郑州450008

出　　处：《周口师范学院学报》2014年第2期82-85,共4页Journal of Zhoukou Normal University

基　　金：河南省科技厅重点科技攻关项目(No.112102210030)

摘　　要：以氧氟沙星为模版分子,α-甲基丙烯酸为功能单体,乙二醇二甲基丙烯酸酯为交联剂,偶氮二异丁腈为引发剂,通过本体聚合制备氧氟沙星分子印迹聚合物.通过一系列单因素实验和正交实验确定最优合成比例,即模板分子、功能单体、交联剂的比例为1∶8∶30,引发剂的用量为单体和交联剂二者总质量的1.0%,65℃油浴的条件下,反应24h.利用紫外-可见光谱分析法对印迹聚合物进行吸附性和选择性测试,优化后合成的印迹聚合物对氧氟沙星的吸附量大于非印迹聚合物,印迹聚合物表现出了更好的选择吸附性.Molecularly imprinted polymers were synthesized by hulk polymerization, using ofloxacin as template, α- methylacrylic acid as functional monomer, ethylene glycol dimethacrylate as crosslinker,2,2 -azobisisobutyronitrile as initia- tor. It was obtained by a series of single factor experiment. The optimizational conditions were obtained by orthogonal ex- periment, the ratio of template molecule, functional monomer and crosslinker was 1 ： 8 ： 30,the initiator dosage was 1.0%, reaction time 24 h at 65℃. The absorption of ofloxacin by molecularly imprinted polymers have better absorption compared with non- imprinted polymers.

关 键 词：氧氟沙星 本体聚合 分子印迹聚合物 

分 类 号：O652[理学—分析化学]