一种有效制备2-氨基-3,5-二硝基-6-氯吡啶及其衍生物的方法  

A Convenient Preparation Method for 2-Amino-3,5-dinitro-6-chloropyridine and Its Derivatives

作　　者：马丛明[1] 侯可辉[1] 刘祖亮[1] 姚其正[1,2] 

机构地区：[1]南京理工大学化工学院,南京210094 [2]中国药科大学药学院,南京210009

出　　处：《有机化学》2014年第3期584-588,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21102125)资助项目~~

摘　　要：研究了2-氨基-3，5-二硝基-6-氯吡啶（4）及其衍生物的制备新方法．以廉价易得的2,6-二氯吡啶（1）为起始原料，通过硝化、氨化、硝化反应步骤得到中间体2-氨基-3，5-二硝基-6．氯吡啶（4），再与氨、叠氮化钠等亲核试剂反应分别得到2-氨基-3，5-二硝基吡啶-6-取代衍生物5-7．研究表明该方法具有原料便宜易得、后处理操作简单和产品纯度高等优点．A novel preparation method for 2-amino-3,5-dinitro-6-chloropyridine （4） and its derivatives was described starting from cheap and easily available 2,6-dichloropyridine （1）. Compound 4 was obtained by nitration, amination and again nitration reaction, followed by reacting with several nucleophilic reagents, such as ammonia, sodium azide to form 2-amino-3,5-dinitropyridine-6-substituted derivatives 5-7, respectively. The results showed that this synthetic route had the advantages of easy-obtained raw materials, simple work-up and high purity product.

关 键 词：制备 2 6-二氯吡啶 2-氨基-3 5-二硝基-6-氯吡啶 亲核取代 

分 类 号：TQ253.2[化学工程—有机化工]