多虑平联合左氧氟沙星和萘哌地尔治疗慢性前列腺炎疗效观察  

The rapeutic efficacy of Doxepin combining with Levofloxacin and Naftopidil for the Treatment of Chronic Prostatitis

作　　者：曹文锋[1] 王亮[1] 王庆堂[1] 黄晓科[1] 杨航[1] 陈卫国[1] 李沙丹[1] 

机构地区：[1]成都军区总医院泌尿外科,四川成都610083

出　　处：《四川医学》2014年第3期326-328,共3页Sichuan Medical Journal

摘　　要：目的观察多虑平联合左氧氟沙星及α1受体阻滞剂萘哌地尔治疗慢性前列腺炎的疗效。方法慢性前列腺炎患者90例,随机分为对照组(左氧氟沙星及萘哌地尔)和治疗照组(多虑平联合左氧氟沙星及萘哌地尔),每组45例,均连续用药4周后观察疗效。结果治疗组治愈7例,显效20例,有效15例,无效3例,总有效率是93.3%;对照组治愈4例,显效16例,有效14例,无效11例,总有效率是75.6%,两组间差异有统计学意义(P<0.05)。治疗前后疼痛评分治疗组为(13.12±5.27)分和(4.38±2.07)分,对照组为(12.56±2.73)分和(6.29±3.35)分(P<0.05);排尿症状评分治疗组为(6.07±2.74)分和(2.95±1.12)分,对照组为(6.72±2.17)分和(4.05±2.39)分(P<0.05),且治疗组治疗后疼痛和排尿症状评分改善均优于对照组(P<0.05)。两组患者均未报告不良事件。结论多虑平联合左氧氟沙星及α1受体阻滞剂萘哌地尔治疗慢性前列腺炎疗效满意,有良好的安全性和耐受性。Objective To study the efficacy of Doxepin Hydrochloride combining with Levofloxacin Hydrochloride and Naftopidil in the treatment of chronic prostatitis. Methods 45 patients in the control group were treated with Levofloxacin Hydro- chloride and Naftopidil, 45 patients in the trial group were treated with Doxepin combine with Levofloxacin and Naftopidi. The ex- pressed Prostate secretion（EPS） examination and the national institute health chronie prostatits symptom index （NIH-CPSI） evalu- ation before and after a 4-week treatment. Results After 4 weeks treatment, the total improved was 93.3% in the trial group and75.6% in the control group （P 〈 0. 05 ） ; Before and after treatment NIH-CPSI pain score was （ 13.12 ± 5.27） and （5.78 ± 2.07） in the trail group, （ 12. 56 ±2. 73） and （6. 29 ±3.35） in the control group; Before and after treatment NIH-CPSI voiding score was （6. 07 ±2. 74） and （2. 95 ± 1.12） in the trail group, （6. 72 ±2. 17） and （4.05 ±2. 39） It was improved more signifi- candy （ P 〈 0. 05 ） for NIH-CPSI pain score and voiding score in the trail group after treatment than before. Two groups of patients did not report adverse events. Conclusion The use of Doxepin combined with Levofloxacin Hydrochloride and Naftopidil was ef- fective and safe in the treatment of chronic prostatitis.

关 键 词：多虑平 左氧氟沙星 萘哌地尔 前列腺炎 

分 类 号：R697.33[医药卫生—泌尿科学]