中药组分及有效成分干预动脉粥样硬化易损斑块相关信号通路的研究进展  

Advancement of Constituents and Active Ingredients of Chinese Herbs in Affecting Signal Pathway for Vulnerable Plaques in Atherosclerosis

作　　者：李晓[1] 刘剑刚[1] 刘龙涛[1] 李浩[1] 郭刚[2] 

机构地区：[1]中国中医科学院西苑医院,北京100091 [2]山东大学齐鲁医院,山东济南250012

出　　处：《中药新药与临床药理》2014年第2期231-235,共5页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金课题(81102721);山东省科技攻关计划(2010GSF10289)

摘　　要：易损斑块的稳定性是继发性血栓是否形成的主要原因,及时识别易损斑块并进行有效的治疗对预防急性冠状动脉综合症(ACS)具有重要意义。中药组分及有效成分对影响动脉粥样硬化(Atherosclerosis,As)易损斑块形成的相关信号通路的作用研究已经取得了一定的成果,对Toll-like receptor4(TLR4)、核转录因子κB(NF-κB)、过氧化物酶体增殖物激活受体γ(PPARγ)、酪氨酸蛋白激酶信号转导子和转录激活子(JAK-STAT)等信号通路具有一定的干预作用,并已从分子水平阐释了中药组分及有效成分稳定As易损斑块的作用机制。The stability of the vulnerable plaques is the main reason for whether secondary thrombosis can generate. It is significant to timely identify the vulnerable plaques and conduct effective treatments to prevent acute coronary syndrome （ACS）. Some achievements have gained in the field of how active ingredients of Chinese herbs affect the signal pathways which pallicipate in the generation of vulnerable plaques in atherosclerosis （As）. Researches have showed that some active ingredients do have intervention effects on the signal pathways, such as Toll-like receptor 4 （TLR4） signal pathway, nuclear factor kappa B （NF-KB） signal pathway,peroxisome proliferator-activated receptor gamma （PPAR 3＇ ） signal pathway, and tyrosine protein kinase signal transducer and transcription activator（JAK- STAT） signal pathway. And they have also explained the mechanisms of these active ingredients in stabilizing vulnerable plaques at the molecular level.

关 键 词：动脉粥样硬化 中药组分 易损斑块 信号通路 

分 类 号：R285.5[医药卫生—中药学]