早期预示肾损伤的过敏性紫癜患儿血中标志物的研究进展  

Research Progress on Blood Biomarkers to Forecast Kidney Injury in Children with Henoch-Schonlein Purpura

作　　者：黄赛平[1] 周太光[1] 

机构地区：[1]泸州医学院附属医院儿科,四川省泸州市646000

出　　处：《中国全科医学》2014年第6期611-614,共4页Chinese General Practice

摘　　要：过敏性紫癜(HSP)为儿童常见病,可发展为紫癜性肾炎,其中部分为严重肾损伤,最终可导致肾衰竭,严重影响患儿的生活质量。目前确诊HSP肾损伤最可靠的证据是肾活检,因肾脏穿刺损伤风险较大,患儿及其家属难以接受。近年来,随着蛋白质组学以及基因分子学的研究进展,对于HSP早期能预示严重肾损伤敏感指标的研究日益受到关注。现将相关研究进展作一综述。Henoch - Schonlein purpura （HSP） is a common disease in children, which could develop into Henoch - Schonlein purpuritic nephritis, or even severe renal injury and resulted in renal failure and can seriously affect children＇s life quality. Currently, the most reliable method to diagnose HSP kidney damage is renal biopsy, which is with high risk and piercing damage, thus not well accepted by children and their parents. Recently, with the progress of the research on proteomics and gene molecular biology, more attention is paid to sensitive blood biomarkers which could predict severe kidney damage in children with HSP. This article reviews the interrelated research progress.

关 键 词：紫癜 过敏性 紫癜性肾炎 血管细胞黏附分子1 半胱氨酸蛋白酶抑制剂 基质金属蛋白酶类 

分 类 号：R554.6[医药卫生—血液循环系统疾病]