脑康泰胶囊对阿尔茨海默氏病大鼠学习记忆作用的影响  

Effects of Naokangtai capsule on the ability of learning and memory of rats with Alzheimer′s disease induced by quinolinic acid

作　　者：杨军[1] 王静[1] 陈荣芳[2] 陈贵海[2] 

机构地区：[1]安徽省医学科学研究所省生物医药重点实验室,合肥23006 [2]安徽医科大学第一附属医院

出　　处：《中国现代应用药学》2001年第1期10-13,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：安徽省九五科技攻关项目,编号9613010-1

摘　　要：目的 :观察脑康泰胶囊对阿尔茨海默氏病模型大鼠学习记忆作用的影响。方法 :采用脑立体定向颅内注射喹啉酸所致阿尔茨海默氏病 (Alzheimer′sdisease,AD)大鼠模型的方法。结果 :脑康泰胶囊可显著增强AD大鼠被动学习和主动学习的能力 ,调节脑组织中单胺类递质含量及血液中相关激素水平 ,并显著改善AD模型大鼠的脑电图。结论 :脑康泰胶囊显著改善AD大鼠学习记忆能力的作用 ,其机制与其调节中枢递质及激素水平等相关。OBJECTIVE:To investigate the effect of memory and learning of Naokangtai capsule on AD rats.METHOD:Experimental model of Alzheimer′s disease was made with rats induced by intracranial injection of quinolinic Acid.RESULTS:Naokangtai capsule could increase the ability of memory and learning of AD rats,adjust the level of monoamine transmitters in the brain and hormones in the blood and improved electro encephalogram of AD rats significantly.CONCLUSION:Naokangtai capsule possesses obvious effects of improving memory and learning of AD rats.

关 键 词：阿尔茨海默氏病 喹啉酸 单胺递质 学习记忆 中医药疗法 脑康泰胶囊 实验研究 

分 类 号：R277.791.6[医药卫生—中医学] R285.5