复方碳酸钙泡腾颗粒剂人体相对生物利用度研究  

The study on relative bioavailability of compound calcium carbonate granules in Human

作　　者：张学农[1] 陶亮[2] 王新玲[2] 周云龙[2] 

机构地区：[1]新疆医科大学药剂学教研室,乌鲁木齐830054 [2]新疆医科大学特丰制药厂

出　　处：《中国现代应用药学》2001年第1期34-37,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的 :考察复方碳酸钙颗粒剂的人体相对生物利用度。方法 :以钙尔奇D6 0 0为对照品 ,原子吸收分光光度法测定 12名自愿受试者口服复方碳酸钙颗粒剂后的尿钙排泄量。结果 :在 12h内 ,复方碳酸钙颗粒剂组 ,钙尔奇D组和空白对照组的平均尿钙排泄总量分别为 12 5 .2 1± 2 6 .6 0 ,12 4.49± 36 .6 0和 6 7.2 4± 19.39mg。集尿期内复方碳酸钙颗粒剂和钙尔奇D尿钙排泄总量的净增值分别为 5 7.97± 2 4.2 4和 5 7.31± 32 .6 8mg。复方碳酸钙颗粒剂的相对生物利用度 10 1.5 0 %。结论 :两种药物的吸收程度相当 ,无统计学差异 (P >0 .0 5 ) ,由尿钙排泄速率推测 ,复方碳酸颗粒剂的吸收速度与钙尔奇D片一致。OBJECTIVE:To study the relative bioavailability of compound calcium carbonate granules in Human.METHODS:Comparing with caltrate D 600 tablets,the cumulate amount of calcium in urine was determined with atomic absorption spectrophotometer after taking compound calcium carbonate granules and caltrate D for 12 volunteers.RESULTS:The average excreteive calcium qualities in urine in three gorups,compound calcium carbonate granules and caltrate D tablets and blankness volunteer groups,were orderly 125.21±26.60, 124.49 ±36.60 and 67.31±19.39mg in 12 hours.Comparing with the space group,the increasing amount of calcium in extracted urine were 57.97 ±24.24mg in compound calcium carbonate granules and 57.31±32.68mg in caltrate D tablets groups.The releative bioavaillability of compound calcium carbonate granules in human was 101.5%.There was no remarkable differentias between two groups(P>0.05).CONCLUSION:According to the urinous drugs excretive rate methods,there was similar absorption rate between two test drugs.

关 键 词：复方碳酸钙 钙尔奇D 人体生物利用度 原子吸收分光光度法 泡腾颗粒剂 

分 类 号：R977.9[医药卫生—药品] R944.27[医药卫生—药学]