孕期生殖道B族溶血性链球菌感染检测的临床意义  

Detection of group B Streptococci causing reproductive tract infections during gestational stage and its clinical significance

作　　者：王莉钦 吴兰芬[1] 韦云龙[2] 

机构地区：[1]杭州市余杭区妇幼保健院产科,浙江杭州311100 [2]杭州市余杭区妇幼保健院检验科,浙江杭州311100

出　　处：《中华医院感染学杂志》2014年第7期1763-1765,共3页Chinese Journal of Nosocomiology

基　　金：余杭区科技计划基金项目(2008-医学-15)

摘　　要：目的：了解孕妇生殖道B族溶血性链球菌（Group B streptococcus ，GBS ）的带菌率，并探讨其对母婴预后的影响。方法2011年1月-2012年10月850例孕妇纳入研究，在孕30～35周时取阴道分泌物行GBS培养；按培养结果分为阳性组104例和阴性组746例，比较两组孕妇一般情况、妊娠结局及新生儿出生后6周内的健康状况差异；数据采用SPSS 15．0软件进行统计分析。结果 GBS阳性组农村户籍30．8％、经产妇19．2％和有流产史15．4％，孕妇比例均显著高于GBS阴性组的10．7％、5．1％和2．6％；GBS阳性组早产22．1％、胎膜早破33．7％，发生率显著高于GBS阴性组的6．2％和19．0％；GBS阳性组新生儿窒息6．7％、新生儿上呼吸道感染9．6％及新生儿肺炎14．4％，均高于GBS阴性组的2．4％、4．4％和6．8％，差异均有统计学意义（P＜0．05）。结论妊娠晚期孕妇生殖道GBS感染对妊娠结局和新生儿健康造成不良影响，有必要对孕妇常规行GBS筛查。OBJECTIVE To understand the carry rate of group B Streptococcus （GBS） in reproductive tract during gestational stage and discuss the effect on prognosis of the mothers and infants .METHODS From Jan 2011 to Oct 2012 ,a total of 850 pregnant women were included in the study ,then the vaginal secretions were sampled at 30~35 weeks of gestation for the culture of GBS ,the subjects were divided into the positive group with 104 cases and the negative group with 746 cases according to the result of culture ,the general status and pregnancy outcomes of the pregnant women and the heath conditions of neonates within 6 weeks after birth were observed and compared between the two groups ,and the statistical analysis was performed with the use of SPSS 15 .0 software .RESULTS Among the pregnant women with GBS cultured positive ,30 .8% had rural household registration ,19 .2% had multipara ,and 15 .4% had the history of miscarriage ,with the proportions significantly higher than 10 .7% , 5 .1% ,and 2 .6% of the pregnant women with GBS culture negative .The incidence of premature birth of the GBS-positive group was 22 .1% ,significantly higher than 6 .2% of the GBS-negative group ;the incidence of premature rupture of membranes of the GBS-positive group was 33 .7% ,significantly higher than 19 .0% of the GBS-negative group .The incidence of asphyxia in the neonates was 6 .7% in the GBS-positive group ,higher than 2 .4% in the GBS-negative bacteria ;the incidence of upper respiratory tract infections in the neonates was 9 .6% in the GBS-positive group ,higher than 4 .4% in the GBS-negative group ;the incidence of pneumonia in the neonates was 14 .4% in the GBS-positive group ,higher than 6 .8% in the GBS-negative group ,the differences were significant （P＆lt;0 .05） .CONCLUSION The GBS infections in reproductive tract at third trimester may have adverse effect on the pregnancy outcomes and neonates＆#39;health;it is necessary to perform the routine GBS screening for the pregnant women .

关 键 词：B族溶血性链球菌 感染 孕妇 新生儿 

分 类 号：R181.32[医药卫生—流行病学]