开颅术后患者降钙素原对颅内感染的诊断分析  

Analysis of using cerebrospinal fluid procalcitonin level to diagnose intracranial infection after craniotomy

作　　者：戴晶[1] 高杰善[1] 董江涛[1] 王刚刚[1] 朱立仓[1] 王业忠[1] 

机构地区：[1]石河子大学医学院第一附属医院神经外科,新疆石河子832008

出　　处：《中华医院感染学杂志》2014年第7期1807-1809,共3页Chinese Journal of Nosocomiology

基　　金：新疆建设兵团科技基金资助项目(2011AB030);新疆石河子大学科研基金项目(SS2012-061)

摘　　要：目的探讨开颅患者术后降钙素原(PCT)对颅内感染的诊断的准确性,使患者得到及时治疗。方法根据医院颅内感染诊断标准,选择2011年5月-2013年5月开颅手术后颅内感染患者30例作为颅内感染组;另选择2011年5月-2013年5月开颅手术后无颅内感染患者30例作为非颅内感染组,采集每例患者的血液和脑脊液送检,检测血液白细胞数、PCT和脑脊液蛋白、白细胞数、PCT,所有数据采用SPSS13.0进行统计分析。结果颅内感染组血液PCT、脑脊液蛋白、脑脊液白细胞数、脑脊液PCT含量均明显升高,与非颅内感染组相比差异有统计学意义(P<0.05);血液白细胞数以10×109/L为阳性阈值,此时敏感性为72.46%、特异性为62.13%、准确性为69.90%;血液PCT以100ng/L为阳性阈值,此时敏感性为67.55%、特异性为83.19%、准确性为79.59%。结论脑脊液PCT敏感性和特异性均高,在开颅手术患者术后颅内感染的诊断中有很高的诊断准确性。OBJECTIVE To explore the diagnostic accuracy of cerebrospinal fluid procalcitonin （PCT ） level in intracranial infection after craniotomy ,so as to provide a quick treatment for patients .METHODS According to diagnostic criteria of intracranial infection in hospital ,30 post-craniotomy patients with intracranial infection after craniotomy from May 2011 to May 2013 were selected as infected group and 30 post-craniotomy patients without intracranial infection after craniotomy from May 2011 to May 2013 were selected as disinfected group .Every patient′s serum and cerebrospinal fluid were taken to test the level of serum WBC ,PCT and CSF proteins ,WBC , PCT and all data were analyzed by SPSS13 .0 software .RESULTS Serum PCT and CSF proteins ,WBC ,PCT values in the infected group were significantly improved and higher than those in the disinfected group （P＆lt;0 .05） . The positive biomarkers of serum WBC was 10 ＆#215; 109/L ,when the sensitivity ,specificity and accuracy were 72 .46% ,62 .13% and 69 .90% .The positive biomarkers of serum PCT was 100ng/L ,when the sensitivity ,speci-ficity and accuracy were 67 .55% ,83 .19% and 79 .59% .CONCLUSION CSF PCT has higher sensitivity and speci-ficity than others and had higher diagnostic accuracy in diagnosis of intracranial infection after craniotomy .

关 键 词：降钙素原 开颅手术 颅内感染 诊断价值 

分 类 号：R446[医药卫生—诊断学]