冠心病患者血小板膜结合纤维蛋白原的定量测定及与血脂的关系  

AN IMMUNOFLUORESCENT QUANTITATIVE MEASUREMENT OF PLATELET BOUND FIBRINOGEN AND THE RELATIONSHIP WITH BLOOD LIPOPROTEIN IN PATIENTS WITH CORONARY ARTERY

作　　者：陈灵[1] 蒋冬贵[2] 

机构地区：[1]深圳市红十字会医院内科三病区,518029 [2]湖南医科大学附属湘雅医院心血管内科,410008

出　　处：《中国现代医学杂志》2001年第1期5-6,共2页China Journal of Modern Medicine

摘　　要：为了探讨冠心病患者血小板聚集性增强的机制 ,我们运用免疫荧光技术 ,测定了血小板膜结合纤维蛋白原 (Fg)在正常人、不稳定心绞痛患者 (UA)的动静脉血中的量 ,以及受检者的血脂。结果表明血小板膜结合Fg的量及LDL在正常人、UA患者的动静脉血中均呈递增趋势 ,差异具有显著性 ,同时动静脉的血小板膜结合Fg的相关性良好且静脉血血小板膜结合Fg的量明显高于动脉血的Fg的量 ,差异具有显著性。它们与血脂中TC及LDL成正相关。提示血小板膜结合Fg用LDL在冠心病的发展过程中是同时存在早期的病理变化 ,都有加重冠状动脉病变的作用。Objective:In order to researching the structural basis and pathogensis of platelet aggregation in patients with coronary artery disease (CAD).Methods:Platelet bound fibrinogen in vein and artery was measured by immunofluorescent in thirty-five patients and twenty-five normal subjects,blood lipoprotein were measured as well.Results:The results were following:(1) Platelet bound fibrinogen in vein and artery in patients with unstable angina pectoris (UA) are higher than normal subjects;(2) Low density lipoprotein (LDL) and TC in CAD patients are higher than normal subjects;(3) Linear correlation analysis revealed that there were perfect positive correlation between the platelet bound fibrinogen in vein and in artery,the same results got between the platelet bound fibrinogen and blood TC and LDL;(4) The platelet bound fibrinogen in vein were higher than that in artery.Conclusions:(1) The higher fibrinogen binding to platelet might be a pathophysiologic basis of unstable angina pectoris;(2) Blood LDL and TC might be a inducing factor in the aggregate of platelets;(3) The platelets were stimulated constantly during the blood flow through artery to vein in CAD patients especially in UA group.

关 键 词：冠心病 血小板 纤维蛋白原 血脂 免疫荧光技术 病理 

分 类 号：R541.402[医药卫生—心血管疾病]