心内直视手术围术期血浆细胞因子的变化  

PROINFLAMMATORY CYTOKINES IN PATIENTS UNDERGOING HYPOTHERMIC CARDIOPULMONARY BYPASS

作　　者：石践[1] 邵展社[1] 李学文[1] 高宏[1] 马良龙[1] 

机构地区：[1]陕西省人民医院心脏外科研究所,西安710068

出　　处：《中国现代医学杂志》2001年第1期9-10,共2页China Journal of Modern Medicine

基　　金：陕西省卫生厅青年科研基金资助!No .98-16

摘　　要：目的 :观察低温体外循环心内直视手术中细胞因子的变化 ,探讨体外循环对其影响。方法 :应用ELISA法测定IL - 8、TNF -α、IL - 10在心脏直视手术围术期的血浆浓度。结果 :IL - 8、IL - 10在体外循环结束后明显高于体外循环前 (P <0 .0 5 ) ,TNF -α无明显变化。结论 :IL - 8、IL - 10作为重要心炎性介质 。Objective:Proinflammatory cytokines,such as tumor-necrosis-factor alpha,interleukin-8,and anti-inflammatory cytokine interleukin-10,may play an important role in patient responses to cardiopulmonary bypass.We sought to define the variety of these cytokines under conditions of hypothermic cardiopulmonary bypass.Methods:Twenty patients were monitored with an arterial catherter.Plasma levels of tumor-necrosis-factor alpha,interleukin-8,and interleukin-10 were measured in peripheral arterial blood before anaesthesia,aortic cannulation,at 5 minutes of CPB,at 10 minutes after aortic declamping,and 4 hours after aortic declamping.Results:Levels of interleukin-8 and interleukin-10 were significantly higher arterial blood after aortic declamping.Tumor necrosis factor-a was not increased markedly.Conclusions:Our data suggest that CPB do caused increase of interleukin-8 and 10,but not tumornecrrosis-factor alpha.

关 键 词：体外循环 IL-8 TNF-Α IL-10 心内直视手术 

分 类 号：R654.2[医药卫生—外科学]