参麦对内毒素诱导的小鼠腹腔巨噬细胞凋亡的保护作用  

EFFECT OF SHEN-MAI AGAINST THE APOPTOSIS OF PERITONEAL MACROPHAGE INDUCED BY LIPOPOLYSACCHARIDE IN MICE

作　　者：罗非君[1] 钟林[1] 尤家騄[1] 肖献忠[1] 王燕如[1] 

机构地区：[1]湖南医科大学病理生理教研究室,长沙410078

出　　处：《中国现代医学杂志》2001年第1期12-14,共3页China Journal of Modern Medicine

摘　　要：目的 :本文观察了参麦对小鼠注射内毒素 (LPS)后腹腔巨噬细胞 (MΦ)凋亡的影响。结果显示 :参麦能抑制LPS诱导的腹腔MΦ凋亡减少 ,使DNA琼脂糖凝胶电泳“梯状”带不明显 ,DNA断裂百分率显著降低 ,同时 ,能使MΦ吞噬功能部分恢复。Macrophage as a king of immune cell plays a central role in the immune response to foreign pathogens and Shen-Mai(SM),as a Chinese medical herb,was reported that could be promote immune response.In the paper we investigated whether SM could inhibit the apoptosis of macrophage induced by lipopolysaccharide (LPS).The results showed that SM decreased DNA fragmentation and apoptotic percentage of macrophage,at the same time,SM also partly inhibited phagocytic ability of macrophage decreased by lipopolysaccharide.Together this,SM could protected the apoptosis of peritoneal macrophage induced by lipopolysaccharide in mice.

关 键 词：内毒素 巨噬细胞 凋亡 小鼠 

分 类 号：R282.710.5[医药卫生—中药学] R285.5[医药卫生—中医学]