促胃肠动力药物研究现状及展望  

Prokinetics now and in the future

作　　者：王宝西[1] 田姣[1] 

机构地区：[1]第四军医大学唐都医院儿科,西安710038

出　　处：《中华实用儿科临床杂志》2014年第7期483-486,共4页Chinese Journal of Applied Clinical Pediatrics

摘　　要：【摘要】胃肠动力障碍性疾病在儿童中的发病率高，但可供选择的促动力剂种类稀少，使临床治疗效果欠佳，长期有效缓解率较低，因此，新型促动力剂的研制一直是儿童胃肠病学研究的重点。目前供成人使用的促动力剂主要有中枢或外周多巴胺受体拮抗剂、血清素激动剂及胃动素受体激动剂，而供儿科可选择的药物种类更少。现主要介绍目前几类促动力剂在成人及儿童中的研究现状，并对未来促动力剂的发展方向作出展望。Gastrointestinal motility disorders are in high incidence in children. Due to moderate prokinetic effects, poor symptomatic responses and the presence of adverse effects ,there is a clear need for new classes of prokinetics. Currently available drug classes in adult include antidopami-nergic agents, serotonergic agents, and motilin-receptor while there are less available drug classes in children. The aim of the present article is to review and address the present use of promotility drugs in the treatment of different gastrointestinal motor disorders ,as well as the potential for future developments.

关 键 词：胃肠动力 促胃肠动力药物 胃肠动力障碍性疾病 

分 类 号：R725.7[医药卫生—儿科]