11酸睾酮男性激素类避孕针可接受性研究  

The Acceptability Study of Injectable Testosterone Undecanoate as a Contraceptive Method in Male Chinese.

作　　者：张立英 刘云嵘 

机构地区：[1]国家计划生育委员会科学技术研究所社会医学研究中心,北京100081

出　　处：《中国计划生育学杂志》2001年第1期24-29,共6页Chinese Journal of Family Planning

基　　金：世界卫生组织人类生殖研究特别规划署

摘　　要：1997年～1999年期间开展了一项由六个研究中心参加的十一酸睾酮男性激素类避孕针的临床多中心避孕效果评价的研究。同期也开展了该方法的可接受性研究。对参加临床效果研究的308名男性志愿者分别于注射避孕针前、注射避孕针后的4个月、8个月、停止注射避孕针后和研究期间退出时进行随访调查,并对受试者的妻子进行的调查。同时,还组织受试者及其妻子、使用其它男性避孕方法的男性以及妻子使用女性避孕方法的男性进行了24组小组专题讨论会。对服务提供者、政策制定者、男性学专家等进行了54次个人深入访谈。定性资料和定量资料综合显示,受试者参与临床试验研究的动机不尽相同,多半参加者是因为女方使用避孕方法有严重副反应,半数因不愿意绝育。大多数受试者觉得该方法可以减轻妻子因避孕而导致的负担。认为打针的方法比绝育术好是由于它有可恢复性。部分受试对象觉得打针后体力增强。有的性功能增强。大多数访谈对象反映近期副反应不大。部分出现痤疮。个别受试对象反映睾丸“变小变软”,身体乏力。注射部位疼痛和使用不方便(每月打针一次大频繁,需查精液,注射药物起效前仍要使用避孕方法,要到门诊注射等)影响其可接受性。农民在农忙时也会很容易忘记去注射。他们希望半年或一年打一针更好。部分人。An acceptability study of the injectable testosterone undecanoate (TU) as a once-a-month male contraceptive method was carried out concurrently with the clinical trial in six provinces in China from 1997 to 1999. The investigation was independent of the clinical trial both in terms of implementation and the responsible investigators. Both quantitative and qualitative social science research approaches were used in this study. 308 men participating voluntarily enrolled into the clinical trial were interviewed. 24 sessions of focus group discussions and 54 sessions of in-depth interviews were conducted among subjects and their wives, potential users, service providers, policy makers from provincial and national levels, and experts engaged in research and development of male methods of contraception. Quantitative data and qualitative data were combined in the analysis. Results show that the main reason for subjects who have one living child joining the trial is to hope relieving wives' suffering from female contraceptive side-effects, while the main reason for subjects who have two or more children joining the trial is to avoid accepting sterilization. Frequency of the injection, semen analysis monthly using other contraceptive method during the suppression made subjects felt this method is not too convenient, especially for those who have to go out for business. There were few side effects reported by the participants, except two subjects had experienced 'paralysis'. 12 of 308 subjects withdrew from the trial within the study period for fearing the influence on their farm work or business work, worrying the effects on health and fertility. Some policy makers said that the introduction of this method would increase providers' workload. Further research is needed to assess the long-term safety of this method, continuation rates, satisfaction among users, and issues related to service delivery.

关 键 词：11酸睾酮 男性避孕 可接受性 

分 类 号：R169.41[医药卫生—公共卫生与预防医学]