鼓索神经切断导致味觉障碍药物治疗的效果观察  

作　　者：李栋[1] 杜欢乐[1] 尤慧华[1] 冯国飞[1] 

机构地区：[1]浙江金华市中心医院(浙江大学金华医院), 321000

出　　处：《浙江临床医学》2014年第4期510-511,515,共3页Zhejiang Clinical Medical Journal

基　　金：金华市科学技术局重点科研项目（2011A32121）

摘　　要：目的观察鼓室成形术中切断鼓索神经导致的味觉障碍患者应用药物干预的疗效，并分析常规中耳炎手术中有无保留鼓索神经的必要性。方法选取鼓室成形术中切断鼓索神经引起味觉障碍患者共60例，随机分为神经营养药（甲钴胺）及改善微循环药（复方丹参）治疗组和常用方法即随访观察味觉恢复组（对照组），各30例。结果所有患者均得到严格术后随访，随访均终止于术后12个月。参照味觉辨认三分法，治疗组味觉恢复26例，对照组17例，差异有统计学意义（P=0．01）。结论在鼓室成形术中切断鼓索神经导致的味觉障碍后，药物治疗有助于患者味觉的恢复；中耳手术中勿损伤鼓索神经，尤其是对于双侧中耳疾患的患者，保留鼓索神经有其必要性。Objective The purpose of this study is to investigate whether clinical drug intervention is feasible and necessary for patients with dysgeusia caused by chorda tympani nerve transection in tympanoplasty, and to evaluate the necessity of preserving chorda tympani nerve in routine surgical procedure for otitis media. Methods Sixty patients with dysgeusia caused by chorda tympani nerve transection in tympanoplasty were divided into two groups, with 30 patients in each group. Patients in experimental group received drug treatment while those in control group did not receive any treatment. Results After follow up of 12 months, recovery from dysgeusia was found in 26 and 17 patients in experimental and control group respectively （ P=0.01 ） . Conclusions Drug treatment is feasible and necessary for patients with dysgeusia caused by chorda tympani nerve transection in tympanoplasty. Chorda tympani nerve injury should be avoided during middle ear operation, especially for patients with bilateral otitis media.

关 键 词：味觉 鼓索神经 甲钴胺 复方丹参滴丸 

分 类 号：R595.3[医药卫生—内科学]