环加氧酶2抑制剂联合化疗增强肺癌免疫及其机制  

COX-2 Inhibitors Combined with Chemotherapy Enhancing the Immune of Lung Cancer and the Mecha-nisms

作　　者：季晓磊[1] 张卿[1] 

机构地区：[1]内蒙古医科大学附属医院呼吸内科,呼和浩特010059

出　　处：《医学综述》2014年第7期1200-1202,共3页Medical Recapitulate

基　　金：国家自然科学基金(30560175)

摘　　要：环加氧酶2(COX-2)在肺癌中高表达并可打破机体的免疫平衡。单纯化疗过程中,肿瘤细胞对药物的不敏感性、某些化疗药物同时存在毒性反应及耐药性、单纯化疗药物作用于机体可能产生的不良反应等,都会使得机体免疫功能下降。针对以上特点,通过调节体内相应细胞因子白细胞介素(IL)10、IL-12、肿瘤坏死因子α、干扰素γ水平而发挥肿瘤免疫作用,探索COX-2抑制剂联合化疗的抗肿瘤效应,从而通过增强肺癌的免疫来提高肺癌治疗的疗效。Cyclooxygenase2 （COX2） high expression in lung cancer can break the body＇s immune balance. In pure chemotherapy tumor ceils are not sensitive to the medication, and toxity and drug resistance may simulta- neously exist in some chemotherapy, and adverse reactions caused pure chemotherapy on the body, may all cause the decline of the body＇s immune function. In view of the above characteristics, regulating the body corresponding cytokines IL-10 ,IL-12 ,TNF-α ,IFN-γ levels to let tumor immunity work, and exploring the anti-tumor effect of COX-2 inhibitors combined with chemotherapy drugs, may improve immunity in lung cancer to improve the cura- tive effect.

关 键 词：环加氧酶2抑制剂 白细胞介素10 白细胞介素12 肿瘤坏死因子Α 干扰素Γ 

分 类 号：R563.9[医药卫生—呼吸系统]