噻托溴铵联合舒利迭对COPD患者肺过度充气及运动耐量的影响  

Effects of Tiotropium Combined with Seretide on Lung Hyperinflation and Exercise Tolerance in Patients with COPD

作　　者：何敏[1] 邝军[1] 朱建勇[1] 张立波[1] 叶青[1] 

机构地区：[1]湖北医药学院附属人民医院呼吸内科一病区,湖北十堰442000

出　　处：《医学综述》2014年第7期1301-1303,共3页Medical Recapitulate

摘　　要：目的探讨噻托溴铵、舒利迭联合用药对慢性阻塞性肺疾病(COPD)稳定期患者肺功能及运动耐量的影响。方法将2012年9月至2013年4月湖北医药学院附属人民医院呼吸内科诊治的46例COPD稳定期患者依据随机数字表法分为两组:对照组(23例)给予舒利迭雾化吸入,每日1吸,每日2次;观察组(23例):应用舒利迭治疗同时给予噻托溴铵治疗,每日1粒。比较两组治疗前、治疗后3个月肺功能改变及运动耐量。结果观察组深吸气量、功能残气量、第一秒用力呼气容积(FEV1)、FEV1占预计值百分比及FEV1/用力肺活量值均较治疗前有显著改善(P<0.05),患者6 min步行距离均有显著增加,平均呼吸困难症状评分显著降低(P<0.05),与对照组比较差异均有统计学意义(P<0.05)。两组不良反应未见明显差异(P>0.05)。结论与单用舒利迭相比,噻托溴铵、舒利迭联合用药更能改善患者肺过度通气,改善患者呼吸困难症状及肺功能,并提高患者运动耐量,值得临床推广及应用。Objective To investigate the effects of therapy of tiotropium combined with seretide on lung function and exercise tolerance in patients with stable chronic obstructive pulmonary disease （COPD）. Methods Forty-six patients with stable COPD admitted to the People＇s Hospital of Hubei Medical College of Respiratory Medicine from Sep. 2012 to Apr. 2013 were divided into two groups based on random number table ：23 patients in the control group were treated with seretide inhalation, I inhalation per time,2 times everyday. 23 patients in the observation group were treated with seretide and tiotrepium, one pill everyday. Pulmonary function changes and exercise tolerance in the two groups were compared before treatment and after 3 months treatment. Results Inspiratory capacity,functional residual capacity,forced expiratory volume in 1 second（FEV1 ） ,FEVI% predicted value and FEVl/foreed vital capacity values in the observation group were significantly improved than before treatment （ P 〈 0.05 ）, six-minute walk distance （6 MWD ） was significantly increased, average breathing difficulty symptom score was significantly lowered （P 〈 0.05 ）, and compared with the control group, there were significant differences（P 〈0.05）. There was no significant difference in adverse events between the two groups（P 〉0.05）. Conclusion Compared with single-use of seretide,combination therapy of tiotropium and seretide can better im- prove pulmonary hyperventilation,improve dyspnea symptoms and lung function, and improve exercise tolerance, which is worthy of clinical application.

关 键 词：噻托溴铵 舒利迭 慢性阻塞性肺疾病 肺功能 运动耐量 

分 类 号：R563[医药卫生—呼吸系统]