板桥党参多糖抗肿瘤活性实验研究  

Experimental Studies on Antitumor Activity of Polysaccharides from Codonopsis Tangshen

作　　者：杨瑾[1] 董兴高[2] 袁德培[1] 熊茂来[2] 

机构地区：[1]湖北民族学院中医药学院,湖北恩施445000 [2]湖北民族学院医学院,湖北恩施445000

出　　处：《湖北民族学院学报（医学版）》2014年第1期6-8,共3页Journal of Hubei Minzu University(Medical Edition)

基　　金：湖北省卫生厅青年科技人才项目(QJX2010-26);湖北民族学院博士启动基金项目(MY2010B003)

摘　　要：目的初步研究板桥党参多糖的抗肿瘤活性。方法 MTT法检测板桥党参多糖体外抗肿瘤活性。对S180荷瘤小鼠灌胃板桥党参多糖,观察肿瘤的生长抑制情况。以最大给药量法对小鼠进行灌胃给药测定板桥党参多糖的急性毒性。结果板党多糖对MCF-7细胞具有显著抑制增殖作用;荷瘤小鼠小、中、大剂量组肿瘤质量明显小于模型对照组(P<0.05),小鼠以最大剂量灌胃给药后全部存活。结论板党多糖具有抑制肿瘤生长的作用。Objective To investigate the antitumor activity of Polysaccharides from Codonopsi~ tan- gshen.Methods Detection of anti-tumor activity in vitro was based on MTT assay, and the analy- sis in vivo was based on $180 tumor-bearing mice fed on Polysaccharides from Codonops~ tang- shen. Acute toxicity was observed on mice with maximum dose. Results Polysaccharides from Codonopsi~ tangshen significantly inhibited the proliferation of MCF-7 cells, tumor mass from tumor-bearing mice with small, medium, large doses was significantly smaller than that of the model group （P〈0.05） .Acute toxicity test mice survived.Conclusion Polysaccharides from Codo- nopsis tangshen significantly inhibited tumor growth.

关 键 词：板桥党参 多糖 抗肿瘤活性 MCF-7 S180 

分 类 号：R285.5[医药卫生—中药学]