小鼠心肌肥厚发展过程中心电图动态变化  

The dynamic alterations of electrocardiogram during progression of mouse cardiac hypertrophy

作　　者：焦宏[1] 张勇[1] 王晓玲[2] 

机构地区：[1]河北北方学院基础医学院 [2]河北北方学院附属第一医院,张家口075000

出　　处：《中国应用生理学杂志》2014年第2期168-171,共4页Chinese Journal of Applied Physiology

基　　金：河北省科技计划项目(12276104D-39)

摘　　要：目的:探讨小鼠心肌肥厚发展过程中心电图的动态变化。方法:复制小鼠压力超负荷性心肌肥厚模型,连续动态监测小鼠从心肌肥厚早期至心力衰竭发展过程中的不同阶段体表心电图改变。结果:①对照组和模型组术后2周内小鼠未见自发性心律失常,而模型组术后5周、9周和13周小鼠出现自发性心律失常,主要表现为频发的室性早搏以及阵发性室性心动过速,心律失常发生率分别为15%、28%和63%。②与同期对照相比,术后2周、5周、9周和13周组动物QT间期以及QTc间期明显延长,分别延长20.4%、32.7%、49.7%、61.0%和27.1%、32.1%、43.9%、59.1%(P<0.01)。③心肌肥厚小鼠心电图的另一个特征为J波变化。所有对照组动物心电图均为正向J波,而模型组动物从2周开始J波正向值下降,5周逐渐变平,到13周时完全翻转。④与同期对照相比,模型组的PR间期没有改变,但术后2周RR间期轻微缩短。结论:心肌肥厚小鼠自发性心律失常发生率逐渐增加,QT间期进行性延长,J波幅值逐渐降低,表明随着疾病的进展心室复极化异常逐渐加重。Objective： To find the characteristic parameters from electrocardiogram （ECG） which is most related to pathological progress, surface ECG was performed in mice at 2, 5, 9 and 13 week post surgery. Methods： Electrocardiogram recordings： The mice were anaes- thetized with tribromoethanol （250 mg/kg, i.p. ）. Lead Ⅱ surface ECG were acquired by using the Biopac System MP150 at a rate of 5 kHz. Results： ①No arrhythmia was observed in Sham and 2-week Band mice. Spontaneous arrhythmias were observed in ECG recordings, with an incidence of 15%, 28% and 63% in 5-, 9- and 13-week Band mice, respectively. Tachyarrhythmias, such as frequent premature ventricular extrasystole, bigeminy, lrigeminy, and paroxysmal tachyeardia were found.②Analysis of ECG recordings revealed a significant prolongation of QT and QTc intervals. Compared with age-matched Sham mice, the increment in QT and QTc intervals was 20.4%, 32.7%, 49.7%, 61.0% and 27.1%, 32.1%, 43.9%, 59.1% at 2, 5, 9 and 13 week, respectively （P 〈 0.01）. （~_）The characteristic change in electro cardiogram was on the J wave. The amplitude of J wave was upward in Sham mice, and it was significantly flattened or inverted in Band mice. ③Except that RR interval at 2 week showed a slight decrease, there was no significant change in PR interval and RR interval in Band mice. Conchision： In the present study, we found that the increase incidence of spontaneous arrhythmias, prologation of QT interval and changes in the amplitude of the J wave in the surface ECG during progression of mouse cardiac hypertrophy and failure, and the progressive pattern indi- cated that a gradual aggravation of the ventriclar repolarization delay in this mouse model.

关 键 词：心肌肥厚 心力衰竭 心电图 小鼠 

分 类 号：R331.3[医药卫生—人体生理学] R443.8[医药卫生—基础医学]