欧米诺汗印法对糖尿病足溃疡发生风险的预测价值  

Neuropad test for sudomotor function to predict the risk of diabetic foot ulceration

作　　者：覃艳[1] 曹瑛[1] 高方[1] 罗祥蓉[1] 李际敏[1] 符霞军[1] 薛耀明[1] 

机构地区：[1]南方医科大学南方医院内分泌代谢科,广东广州510515

出　　处：《南方医科大学学报》2014年第4期560-562,共3页Journal of Southern Medical University

基　　金：糖尿病防治中心国际合作研究项目(粤财工[2010]207号)

摘　　要：目的探讨欧米诺汗印法对糖尿病足溃疡(DFU)发生风险的预测价值。方法以振动觉阈值(VPT)作为评估DFU发生风险的标准将725例2型糖尿病(T2DM)患者分为DFU高危组和非高危组。利用受试者工作特征(ROC)曲线比较欧米诺汗印法与10 g尼龙单丝(10 g SWMF)检查对DFU发生风险的预测价值。结果 725例T2DM患者中DFU高危组占6.1%,该组患者的年龄、DM病程、欧米诺颜色完全变化(CCC)时间及10 g SWMF异常率均高于非高危组(P<0.01)。ROC曲线提示欧米诺CCC时间对DFU发生风险的预测作用优于10 g SWMF,前者ROC曲线下面积约0.8,最佳切点为22.25 min。结论欧米诺汗印法能有效预测DFU发生风险,在预防DFU中具有重要应用价值。Objective To assess the predictive value of Neuropad test on occurrence of diabetic foot ulceration （DFU） among type 2 diabetic patients. Methods We divided 725 cases of type 2 diabetic patients into the high-risk and the non-high-risk groups of DFU based on the results of vibration perception thresholds（VPT） examination, which was widely used as a criteria for predicting DFU. Receiver operating characteristic （ROC） analysis was used to compare the effectiveness of Neuropad with 10 g Semmes-Weinstein monofilament （10 g SWMF） testing in predicting the risk of DFU. Results Among 725 patients of type 2 diabetes, 6.1% were at a high risk of DFU. Compared to non-high-risk group, patients in high-risk group had older age, longer diabetes duration, higher values of complete colour change time （CCC time） of Neuropad and higher abnormal rate of 10 g SWMF （P〈0.01）. CCC time of Neuropad was shown to be better in predicting the risk of DFU than 10 g SWMF, and the area under the ROC curve was about 0.8, and the best cut-off value was 22.25 min. Conclusion Neuropad is an effective means for predicting of the risk of DFU, and can be used to prevent diabetic foot ulceration.

关 键 词：欧米诺 泌汗功能 糖尿病足溃疡 

分 类 号：R587.2[医药卫生—内分泌]