盐酸乙哌立松、塞来昔布和甲钴胺三药联用在腰椎间盘突出症的疗效  

Efficacy of combined use of eperisone hydrochloride,celecoxib and mecobalamin in patients with lumbar disc herniation

作　　者：邹俊[1] 袁晨曦[1] 张志刚[1] 刘凌[1] 杨惠林[1] 

机构地区：[1]苏州大学附属第一医院骨科,江苏省215006

出　　处：《江苏医药》2014年第7期774-776,共3页Jiangsu Medical Journal

基　　金：卫生部公益性行业专项基金(201002018);江苏省骨科临床医学研究中心(BL2012004);江苏省骨外科临床医学中心(ZX201106)

摘　　要：目的评价盐酸乙哌立松、塞来昔布和甲钴胺三药联用在腰椎间盘突出症患者的疗效。方法 100例腰椎间盘突出症患者随机均分为盐酸乙哌立松、塞来昔布和甲钴胺三药联用组(A组)和塞来昔布、甲钴胺治疗对照组(B组)。采用视觉模拟评分法(VAS)评定疼痛程度,日本骨科学会(JOA)评分评估功能改善情况。结果与治疗前相比,A组和B组治疗后的VAS疼痛评分降低(P<0.05),JOA评分增加(P<0.05)。A组治疗后的VAS疼痛评分低于B组(P<0.05),而JOA评分高于B组(P<0.05)。结论盐酸乙哌立松、塞来昔布和甲钴胺三药联用治疗腰椎间盘突出症的临床效果优于塞来昔布和甲钴胺。Objective To evaluate the clinical efficacy of combined use of eperisone hydrochloride, celecoxib and mecobalamin in the patients with lumbar disc herniation. Methods A total of 100 patients with lumbar disc herniation was equally randomized into two groups of A（treated with eperisone hydrochloride, celecoxib and mecobalamin） and B （treated with celecoxib and mecobalamin）. The degree of pain was assessed by visual analogue scale（VAS）, and the improvement of function was evaluated by Japanese Orthopaedic Association（JOA） scoring. Results Compared with before, VAS pain scores were decreased after treatment （P〈0. 05）, while JOA scores were increased in groups of A and B（P〈0. 05）. After treatment, VAS score was lower, JOA score was higher,in group A than those in group B（P〈0. 05）. Conclusion Clinical efficacy of combined use of eperisone hydrochloride, celecoxib and mecobalamin is better than celecoxib and mecobalamin in the treatment of patients with lumbar disc herniation.

关 键 词：腰椎间盘突出症 

分 类 号：R681[医药卫生—骨科学]