成骨细胞特异性转录因子2与乳腺癌  

Runx2 and Breast Cancer

作　　者：付晓珍[1,2] 李洪艳[1,2] 张叶军[1,2] 屈超[1,2] 钟广英 刘晶[3] 邹伟[1,2] 

机构地区：[1]辽宁师范大学生命科学学院,大连116081 [2]辽宁省生物技术与分子药物研发重点实验室,大连116081 [3]大连医科大学附属第一医院中英再生医学应用研究中心,大连116011

出　　处：《生物化学与生物物理进展》2014年第4期332-336,共5页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(30970353;30570225);科技部国家科技合作专项(2010DFR30850)资助项目~~

摘　　要：Runx2为成骨细胞特异性转录因子,调控成骨细胞分化和骨组织的形成.近年来研究表明,Runx2在乳腺癌中可以激活与癌症转移相关的骨基质、黏附蛋白、金属蛋白酶以及血管内皮生长因子,并且Runx2可以与一些联合抑制剂或激活剂形成调控复合体,在亚核结构域中存在,调节基因的转录以及间接地影响乳腺癌细胞的信号通路.除此之外,Runx2还可以与雌激素受体相互作用在某种程度上解除雌激素及其受体在乳腺癌发展中的调控作用.本文主要概括Runx2在乳腺癌中的作用机制,重点综述Runx2在乳腺癌中与雌激素受体相互作用的研究进展.Runx2 is an osteoblast-specific transcription factor, which regulates osteoblast differentiation and bone formation. In breast cancer, Runx2 activates expression of bone matrix and adhesion proteins, matrix metalloproteinase and angiogenic factors that has long been associated with metastasis. Runx2 forms co-regulatory complexes with some co-activator and co-repressor proteins that are organized in subnuclear domains to regulate gene transcription and mediates the responses of cells to signaling pathways activate in breast tumors. In addition, Runx2 could also interact with the estrogen receptors in some extent to discharge the effect of estrogen and its receptors on the development of breast cancer. This article mainly summarizes Runx2＇s roles in breast carcinoma and its interaction with estrogen receptors.

关 键 词：Runx2 乳腺癌 骨转移 信号通路 雌激素受体 

分 类 号：Q2[生物学—细胞生物学]