孕妇的年龄和孕前体质指数与血脂水平的关系研究  

Relationship between age, BMI and blood lipid levels among pregnant women

作　　者：王箭[1] 郭进强[1] 崔俊英[1] 罗炳德[1] 

机构地区：[1]南方医科大学公共卫生与热带医学学院,广东广州510515

出　　处：《热带医学杂志》2014年第3期286-289,共4页Journal of Tropical Medicine

基　　金：国家自然科学基金-广东省政府联合基金(U0632009)

摘　　要：目的探讨孕妇的年龄、孕前体质指数与妊娠妇女血脂水平的关系。方法随机选取2012年3月至2013年5月到医院进行正常产检的400名健康孕妇，按照不同的年龄分为适龄组（≤35岁）和高龄组（〉35岁），不同的孕前体质指数（BMI）分为正常组和超重组，检测各组孕妇不同时期的血脂水平，分析孕妇的年龄和孕前体质指数对孕妇血脂水平的影响。同时，选取门诊体检的年龄为16～45岁的50名健康妇女作为对照组。结果450名被调查对象，其孕晚期的甘油三脂（TG）、总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）分别为（3．34±1．86）mmol／L、（6．85±2．19）mmol／L、（3．52±1．84）mmol／L，孕早期为（1．41±1．46）mmol／L、（4．51±2．12）mmol／L、（2．74±2．09）mmol／L，孕晚期均较孕早期偏高，血脂指标均随着孕周的进展而逐渐增高（P〈0．05）；适龄组和高龄组的TG、TC和LDL—C均值分别为（2．05±1．68）mmol／L、（5．39±2．16）mmol／L、（2．92±1．45）mmol／L和（2．45±1．87）mmol／L、（5．83±2．46）mmol／L、（3．21±1．92）mmol／L，高龄组的血脂指标比适龄组高（P〈0．05）。同时，正常体重组和超重组的TG、TC和高密度脂蛋白胆固醇（HDL-C）、LDL．C的均值分别为（2．15±1．78）mmol／L、（5．30±2．37）mmol／L、（1．86±1．26）mmo｜／L、（2．97±1．91）mmol／L和（2．4±1．57）mmol／L、（5．75±2．56）mmol／L、（1．83±1．25）mmol／L、（3．34±1．89）mmol／L，超重组的血脂指标均比正常体重组高，尤以孕中晚期明显，差异有统计学意义（P〈0．05）。结论健康妊娠期妇女的血脂水平会随着孕周的进展而逐渐升高。血脂指标的升高在妊娠期间相对是一种正常的生理现象。高龄妊娠会增加血脂异常发生的风险。孕期的血脂代谢变化与孕前体质指数相关。Objective To explore the relationship between age, pre-pregnant BMI and blood lipid levels among pregnancy women in Guangdong. Methods Randomly selected 400 pregnant women who underwent obstetrical examination in Guangdong Hospitals and 50 healthy no-pregnant women as the control group from March 2012 to May 2013.Then divided into procreation age group（ ≤35 years） and advanced maternal age group（〉35 years） according to different ages. Meanwhile, all the women were divided into normal-weight group（BMI ≤24） and over-weight group （BMI〉24） based on the pre-pregnant BMI. Results All the respondents, the TG, TC and LDL-C levels were （3.34±1.86）mmol/L, （6.85± 2.19）mmol/L and （3.52±1.84）mmol/L,respectively,in late pregnancy was apparently increased in contrast to （1.41± 1.46） mmol/L, （4.51 ±2.12） mmol/L, （2.74 ±2.09） mmol/L, respectively, in early pregnancy. The lipid levels increased gradually along with their gestational age （P〈0.05）. Meanwhile, the TG, TC and LDL-C levels were （2.05±1.68）mmol/L, （5.39±2.16）mmol/L, （2.92±1.45）mmol/L,respectively,at procreation age was significantly blow in contrast to （2.45± 1.87）mmol/L, （5.83±2.46）mmol/L, （3.21±l.92）mmol/L, respectively, in advanced maternal age group. In addition, the TG,TC,HDL-C and LDL-C levels were （2.15±1.78）mmol/L, （5.30±2.37）mmol/L, （1.86±1.26）mmol/L, （2.97± 1.91）mmol/L, respectively,in normal-weight group as well as （2.4±1.57）mmol/L, （5.75±2.56）mmol/L, （1.83±1.25） mmol/L, （3.34± 1.89） mmol/L, respectively, in over-weight group.It showed that all the blood lipid levels were higher in the over-weight group, especially at the mid-pregnancy and late-pregnancy period. Conclusions The lipid levels will be increased along with the progress of the gestational age, it is a physiological phenomenon in a reasonable range for the pregnant women. Age and pre-pregnant BMI is associated with the metabolism of lipidemia.

关 键 词：年龄 孕前体质指数 血脂水平 

分 类 号：R589.2[医药卫生—内分泌]