Extrinsic inhibitors in axon sprouting and functional recovery after spinal cord injury  

作　　者：Jessica M.Meves Binhai Zheng 

机构地区：[1]Neurosciences Graduate Program, Department of Neurosciences, University of California San Diego, School of Medicine, 9500 Gilman Drive,MC 0691, La Jolla, CA, USA

出　　处：《Neural Regeneration Research》2014年第5期460-461,共2页中国神经再生研究（英文版）

基　　金：supported by grants from NIH/ NINDS (R01NS054734);the California Institute for Regenerative Medicine;the Craig H. Neilsen Foundation and Wings for Life Spinal Cord Research Foundation

摘　　要：The limited axonal growth after central nervous system （CNS） injury such as spinal cord injury presents a major challenge in promoting repair and recovery. The literature in axonal repair has focused mostly on frank regeneration of injured axons. Here, we argue that sprouting of uninjured axons, an innate repair mech- anism of the CNS, might be more amenable to modulation in order to promote functional repair. Extrinsic inhibitors of axonal growth modulate axon sprouting after injury and may serve as the first group of therapeutic targets to promote functional repair.The limited axonal growth after central nervous system （CNS） injury such as spinal cord injury presents a major challenge in promoting repair and recovery. The literature in axonal repair has focused mostly on frank regeneration of injured axons. Here, we argue that sprouting of uninjured axons, an innate repair mech- anism of the CNS, might be more amenable to modulation in order to promote functional repair. Extrinsic inhibitors of axonal growth modulate axon sprouting after injury and may serve as the first group of therapeutic targets to promote functional repair.

关 键 词：CNS OMgp Extrinsic inhibitors in axon sprouting and functional recovery after spinal cord injury 

分 类 号：R651.2[医药卫生—外科学]