类风湿患者血清颈动脉硬化与炎性因子相关性分析  

Correlation between Carotid Atherosclerosis and Inflammatory Factors in Patients with Rheumatoid

作　　者：丁艳杰[1] 赵清[1] 王来芳[1] 苏培培[1] 王婧[1] 张冰毅[1] 张媛[1] 

机构地区：[1]河南大学淮河医院风湿免疫科,河南开封475000

出　　处：《昆明医科大学学报》2014年第4期50-53,共4页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81102247)

摘　　要：目的探讨类风湿患者血清颈动脉硬化与炎性因子相关性分析及临床意义.方法选择缓解期类风湿患者的92例,分为无颈动脉硬化组(A组)45例,合并颈动脉组(B组)47例,同时选择健康人群40例作为对照组(C组).分别检测TNF-α、IL-17、CRP、IMT及ICAM-1、VCAM-1.结果 A组TNF-α、IL-17较C组均存在显著性升高(P<0.05),B组TNF-α、IL-17、CRP较A组、C组均差异有统计学意义(P<0.05).A组IMT、ICAM-1、VCAM-1较C组均存在显著性升高(P<0.05),B组IMT、ICAM-1、VCAM-1较A组、C组均有显著升高(P<0.05).TNF-α与IMT、ICAM-1、VCAM-1呈显著正相关(P<0.05),IL-17与ICAM-1、VCAM-1显著正相关(P<0.05),CRP与IMT、ICAM-1、VCAM-1未见显著相关性(P>0.05).结论稳定期类风湿患者炎性因子及颈动脉硬化密切相关,共同促进颈动脉硬化的发生.Objective To investigate the correlation between carotid atherosclerosis and inflammatory factors in patients with rheumatoid and its clinical significance. Methods 92 patients with rheumatoid were divided into non- carotid atherosclerosis group （group A 45 cases）, and carotid artery （group B 47 cases）, while 40 cases of healthy people were selected as a control group （ group C） . Serum levels of TNF-α , IL-17, CRP, IMT and ICAM-1, VCAM-1 were detected. Results Serum levels of TNF-α, IL-17 of patients in A group were significantly higher than those in group C （P〈O.05） , Serum levels of TNF- α , IL-17, CRP of of patients in group B were significantly different to group A and group C （P〈0.05） . Serum levels of IMT, ICAM-1, VCAM-1 of A group were significantly higher than those in group C （P〈O.05） , Serum levels of IMT, ICAM-1, VCAM-1 of group B were significantly higher than those in group A and group C （P〈O.05） , Serum levels of TNF-ct and IMT, ICAM-1, VCAM-1 showed a significant positive correlation （P〈0.05） , Serum levels of IL-17 and ICAM-1, VCAM-1 showed significant positive correlation （P〈0.05）, Serum levels of CRP and IMT, ICAM-1 , VCAM-1 showed no significant correlation （P〉O.05） Conclusion Inflammatory cytokines and carotid atherosclerosis are closely related, and synergically promote the incidence of carotid artery atherosclerosis.

关 键 词：类风湿 颈动脉硬化 炎性因子 MMPS 粘附因子 

分 类 号：R543.4[医药卫生—心血管疾病]