心脏死亡供肾肾移植19例临床分析  

Clinical Analysis of 19 Cases of Renal Transplantation Donated after Cardiac Death

作　　者：孙洵[1] 宋永琳[1] 赵永恒[1] 王丽军[1] 郑昕[1] 

机构地区：[1]昆明市第一人民医院,云南昆明650011

出　　处：《昆明医科大学学报》2014年第4期102-107,共6页Journal of Kunming Medical University

摘　　要：目的探讨终末期肾病患者接受DCD供者肾肾移植后的恢复情况及DCD供体对受者及移植物术后的影响．方法分析昆明市第一人民医院19例终末期肾病患者接受DCD捐献后肾移植的临床资料，对其术前、术后的诊疗及血肌酐（sCr）、移植物及受者存活情况进行回顾性分析．结果19例患者手术全获成功．术后无1例原发性移植物无功能（PNF）病例发生．供体sCr正常的6例，供给11例受体中7例发生肾功能延迟恢复（DGF），发生率为63．6％；供体sCr（184～504μmol/L）异常的8例，供给的8例受者均发生DGF，发生率为100％；19例受体中有1例（5．3％）发生超急性排斥反应，移植肾丢失；有2例术后分别出现严重尿瘘和严重骨髓移植．18例受者接受随访，随访时间为3～12个月，平均7个月，移植肾功能完全恢复正常．结论DCD是目前我国器官来源的重要部分，是解决我国器官移植面临的器官短缺的一个非常有潜力的办法，并且有着较好的短中期预后．Objective To introduce clinical experience for renal transplantation donated after cardiac death by reviewing the clinical data of renal transplantation donated after cardiac death, to evaluate the recovery of patients with end-stage disease receiving renal transplantation from cardiac death donors, and to assess graft survival in China from this type of donor. Methods Data of 19 cases of renal transplantation donated after cardiac death, were retrospectively analyzed. We retrospectively analyzed the data on the preoperative and postoperative serum creatinine concentrations, the survival of recipients and allografts with a view to investigating prognoses after this type of renal transplantation. Results All operations were successful. Primary non-function （PNF） did not occur in any of the 19 recipients, sCr is normal of the 6 cases donors, Delayed graftfunction （DGF） occurred in 7 of 11 （37.5%） recipients, sCr （184-504μ mol / L） is abnormalities of the 8 Donor cases. Delayed grafffunction （DGF） occurred in 8 （100%） recipients. 1 of 19 （5.3%） recipients developed hyperacute reject ion during the surgery. Two recipients developed urinary fistula and bone marrow transplant.18 recipients follow-up of 3-12 months, Renal function returned to normal. Conclusions Organ donation after cardiac death can offer more organs for ta＇ansplantation. It is a very promising way to solve the shortage of organs.

关 键 词：肾移植 心脏死亡器官捐献 效果 

分 类 号：R617[医药卫生—外科学]