2型糖尿病肾病患者血清PEDF、CRP、IL-6水平与尿白蛋白排泄率相关性分析  

Correlation between Serum PEDF, CRP, IL-6 and the Excretion Rate of Urinary Albumin in Patients with Type 2 Diabetic Nephropathy

作　　者：陈孝红[1] 李江[1] 高颖斐[1] 杨成凤[1] 

机构地区：[1]昆明医科大学第二附属医院检验科,云南昆明650101

出　　处：《昆明医科大学学报》2014年第4期121-123,共3页Journal of Kunming Medical University

摘　　要：目的探讨2型糖尿病(T2DM)肾病患者血清色素上皮源因子(PEDF)、C反应蛋白(CRP)、白细胞介素6(IL-6)水平变化及其与尿白蛋白排泄率的相关性.方法选取30例健康对照,126例T2DM患者,依据24 h尿微量白蛋白排泄率(UAER)的高低将患者分为尿白蛋白排泄正常组(NA)45例,微量白蛋白增高,尿蛋白定性阴性组(MA)50例,临床蛋白尿(尿蛋白定性阳性,PR)组31例.采用酶联免疫法检测血清IL-6、PEDF水平,免疫比浊法检测血清CRP,免疫比浊法检测尿微量白蛋白.结果 T2DM患者血清PEDF、CRP、IL-6水平显著高于健康对照组(P<0.05);MA组患者血清PEDF、CRP、IL-6水平显著高于NA组(P<0.05);PR组患者血清PEDF、CRP、IL-6水平显著高于MA组(P<0.05).T2DM患者血清PEDF、CRP、IL-6水平与尿微量白蛋白的排泄率成正相关.结论血清PEDF、CRP、IL-6水平在T2DM患者中显著增高,并随尿白蛋白的严重程度而逐渐升高.血清PEDF、CRP、IL-6水平的升高可能参与了糖尿病肾病的发生和发展.Objective To investigate the serum levels of PEDF, CRP, IL-6 , and to analyze their correlation with the excretion rate of urinary albumin in patients with type 2 diabetic nephropathy. Methods ELISA was used to detect the serum levels of PEDF , IL-6 and immunoturbidimetry was used to detect the urinary albumin excretion, CRP in 30 healthy controls and 126 type 2 diabetic patients, including 45 with normal urinary albumin excretion rate （NA group） , 50 with microalbuminuria （MA, group） , and 31 with over diabetic nephropathy （PR group） Results The serum levels of PEDF, CRP, IL-6 levels of patients in NA group, MA group and PR group were significantly higher than the control group （P〈O.05） . The serum levels of PEDF, CRP, IL-6 were positively correlated with the excretion rate of urinary albumin. Conclusions Serum levels of PEDF, CRP, IL-6 significantly increase in type 2 diabetic patients, and the magnitude of PEDF, CRP, IL-6 is related to the severity of diabetic nephropathy. The increase of serum levels of PEDF, CRP, IL-6 may be involved in the development of diabetic nephropathy.

关 键 词：糖尿病肾病 尿白蛋白 色素上皮源因子 白细胞介素 

分 类 号：R587.1[医药卫生—内分泌]