孕产妇血清中ω-3多不饱和脂肪酸与产后抑郁症的相关性  

Analysis of Correlation between Serum ω-3 Polyunsaturated Fatty Acids of Pregnant Women and Postpartum Depression

作　　者：苏虹[1] 孙洪丽[1] 张静[1] 范薇[1] 

机构地区：[1]昆明市妇幼保健院,云南昆明650028

出　　处：《昆明医科大学学报》2014年第4期138-144,共7页Journal of Kunming Medical University

摘　　要：目的初步探讨孕产妇血清中花生四烯酸(AA)、二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)3种ω-3多不饱和脂肪酸与产后抑郁症发生的关系.方法采用爱丁堡产后抑郁量表(Edinburgh Postnatal Depression Scale,EPDS)评价孕妇的抑郁程度.以EPDS评分≥10分视为抑郁阳性.选择足月妊娠(孕37周)孕妇并分别在产前和产后的门诊随诊时完成EPDS调查问卷,并检测其AA、EPA和DHA的血清水平进行分析,采用Logistic回归分析对产后抑郁症的相关因素进行分析.结果 528例孕妇中发生产后抑郁症者96例,发生率为17.0%.通过对产前和产后的AA、EPA和DHA血清水平分别进行比较,产前均无统计学差异(P>0.5);产后抑郁症产妇EPA和DHA血清水平明显低于无产后抑郁症孕妇(P<0.5),EPDS评分,与产后的EPA和DHA血清水平呈负相关(相关系数分别为rs=-0.424和rs=-0.609).进行非条件的Logistic回归分析,家庭关系是影响产妇产后抑郁症的独立因素(P=0.027),其余均无统计学意义(P>0.5).结论产后抑郁症的发生与产妇产后的EPA和DHA血清水平呈负相关.家庭关系不融洽和近期有很难受事件是发生抑郁的危险因素,而EPA和DHA含量是发生抑郁的保护因素.Objective To preliminarily study the relation between ω-3 polyunsaturated fatty acids （AA, EPA and DHA） level of pregnant women and postpartum depression. Methods Edinburgh Postnatal Depression Scale （EPDS） was used to evaluate the depression level of pregnant women. The EPDS score ≥ 10 was regarded as depression positive. During 37 weeks and after delivery 3 days, we detected serum levels of AA, EPA and DHA. Logistic regression analysis model was used to analyze the related factors of postpartum depression. Results In 528 pregnant women, 96 got postpartum depression, the incidence rate of postpartum depression was 17%. By comparing serum levels of AA, EPA and DHA of prenatal and postpartum women, there were no statistically difference in prenatal cases （P〉0.5） ; the serum levels of EPA and DHA of postpartum women who got depression were obviously lower than those of postpartum women without depression （P〈0.5） . The scores of EPDS were negatively correlated to EPA and DHA （rs = -0.424 and rs =-0.609, respectively） . Unconditioned Logistic regression analysis showed that family relation was the independent factors affecting postpartum depression （P = 0.027） .There was no statistically difference among the rest factors. Conclusion The risk of postpartum depression is negatively correlated to postpartum women＇s serum levels of EPA and DHA. Unharmonious family relationship and mishap are potential factors that would affect postpartum depression, by contrast, the content of EPA and DHA paly protecting role in postpartum depression which prevent postpartum women from getting depression.

关 键 词：孕产妇 不饱和脂肪酸 产后抑郁症 

分 类 号：R714.7[医药卫生—妇产科学]