糖尿病大血管并发症与血清高分子质量脂联素水平的相关性  

Correlation of plasma high-molecular-mass adiponectin with macrovascular diseases in type 2 diabetes mellitus

作　　者：刘超[1] 郑桃林[1] 杜万红[1] 杨柳[1] 

机构地区：[1]解放军第163医院老年病科,长沙410003

出　　处：《中华老年多器官疾病杂志》2014年第3期215-218,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

摘　　要：目的探讨2型糖尿病大血管并发症与血清高分子质量脂联素（HMM-ADPN，H-ADPN）水平之间的相关性。方法选取2010年12月至2012年12月接受治疗的106例2型糖尿病患者，分为单纯2型糖尿病组（A组，n=66）和2型糖尿病合并大血管病变组（B组，n=40）。测量所有受试者的身高、体质量、血压，同时分别测定高密度脂蛋白胆固醇（HDL．C）、低密度脂蛋白胆固醇（LDL-C）、三酰甘油（TG）、总胆固醇（TC）、糖化血红蛋白（HbAlc）、空腹血糖（FBG）、高敏C．反应蛋白（hs-CRP）、血清总脂联素（ADPN）、H．ADPN、空腹胰岛素（FINS）、颈动脉内膜中层厚度（CIMT）等。结果两组间血清H-ADPN水平差异有统计学意义（P〈0．05），多因素logisticl回归分析显示，调整年龄、性别、体质量指数（BMI）及hs．CRP等因素后血清H．ADPN水平与HDL-C水平呈显著正相关（P〈0．05），与收缩压及CIMT呈负相关（P〈0．05）.结论血清H．ADPN水平在糖尿病动脉粥样硬化过程中可能起重要作用，与2型糖尿病大血管并发症的发生和发展相关。Objective To explore the relationship between plasma level of high-molecular-mass adiponectin （HMM-ADPN, H-ADPN） and macrovascular diseases in patients with type 2 diabetes mellitus. Methods A total of 106 patients with type 2 diabetes admitted in our department and Department of Endocrinology from December 2010 to December 2012 were enrolled in this study. These patients were divided into type 2 diabetes group （group A, n = 66） and type 2 diabetes accompanied with macrovaseular complications group （group B, n = 40）. Their height, body mass index （BMI）, blood pressure and high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C）, triglycerides （TG）, total cholesterol （TC）, hemoglobin Ale （HbAle）, fasting blood glucose （FBG）, fasting insulin （FINS）, high-sensitivity C reactive protein （hs-CRP）, total-adiponectin （ADPN）, H-ADPN, carotid intima-media thickness （CIMT） and other indices were measured and calculated. And the results were compared between the 2 groups. Results Plasma H-ADPN was significantly lower in group B than in group A （P 〈 0.05）. Multivariate regression analysis revealed that serum level of H-ADPN level was positively correlated with that of HDL-C （P 〈 0.05）, but was negatively correlated with systolic blood pressure and CIMT （P 〈 0.05） after adjustment for age, gender, BMI and hs-CRP. Conclusion Plasma H-ADPN level might play an important role in the atherosclerosis in type 2 diabetes patients, and be involved in the incidence and development of macrovascular complications in them.

关 键 词：脂联素 糖尿病 2型 糖尿病并发症 动脉粥样硬化 

分 类 号：R587.2[医药卫生—内分泌]