男性体内睾酮水平与阿尔兹海默症关系的meta分析  

Meta-analysis on the Relationship Between Male Testosterone Levels and Alzheimer's Disease

作　　者：王硕[1] 张宏博[1] 胡文珠[1] 张茹[1] 朱凯锦 

机构地区：[1]苏州大学公共卫生学院

出　　处：《中外医疗》2014年第7期3-6,共4页China & Foreign Medical Treatment

基　　金：大学生创新创业训练计划资助

摘　　要：目的探讨男性体内睾酮水平与阿尔兹海默症关系。方法制定文献检索策略,检索中外数据库,根据制定的文献纳入和剔除标准筛选文献,依据Newcastle-Ottawa Scale(NOS)文献评价体系进行文献质量评价。通过统计软件RevMan5.0对数据进行meta分析、异质性检验和发表偏倚评估,得出合并后的WMD值及其95%CI。结果纳入11篇文献,其中英文文献10篇,中文文献1篇。Meta分析显示合并WMD=-0.39(95%CI:-0.76^-0.02),P=0.04。结论阿尔兹海默症男性患者体内睾酮水平比正常男性体内睾酮水平低。Objective To explore the relationship between the male testosterone levels and Alzheimer＇ s disease. Methods Electronic search strategy was carried out among the databases from home and abroad to collect qualified research papers according to the inclusion and exclusion criteria, the qualities of the included researches were evaluated by the Newcastle-Ottawa Scale （NOS） system. RevMan（5.0） was used for data recta-analysis including heterogeneity testing and the assessment of publication bias. The combined WMD values and their 95% CI were calculated. Results A total of 11 researches were included, including 10 English researches and 1 Chinese research. The meta-analysis showed the average WMD is -0.39（95%CI：-0.76-0.02）, P=0.04. Conclusion The results suggested that the testosterone levels of men with Alzheimer＇ s disease are lower than those of the normal population.

关 键 词：阿尔兹海默症 睾酮 性激素 META分析 

分 类 号：R471[医药卫生—护理学]