高频振荡通气治疗重症新生儿呼吸窘迫综合征疗效探讨  

Efficacy of High Frequency Oscillation Ventilation in the Treatment of Severe Neonatal Respiratory Distress Syndrome

作　　者：李炎[1] 

机构地区：[1]广东省梅州市人民医院新生儿科,广东梅州514031

出　　处：《临床医学工程》2014年第4期409-410,共2页Clinical Medicine & Engineering

基　　金：广东省梅州市科技局项目(项目编号:2010B41)

摘　　要：目的探讨高频振荡通气(HFOV)治疗重症新生儿呼吸窘迫综合征(RDS)的疗效及安全性。方法 88例重症RDS病例随机分成两组,分别采用高频振荡通气(研究组,54例)和常频机械通气(对照组,34例),统计治疗后患儿的吸氧浓度(FiO2)、动脉氧分压(PaO2)、肺泡动脉氧分压比值(a/APO2)、呼吸指数(OI)及治疗后的疾病转归、并发症情况。结果两组患儿上机后PaO2均显著改善;与对照组相比,研究组治疗12、24、48小时后FiO2、OI显著下降,a/APO2显著上升(P<0.05);研究组上机时间、氧疗时间及住院时间均较对照组短(P<0.05);两组患儿的存活率及并发症发生率差异无统计学意义。结论高频振荡通气能更好地改善高重症RDS患儿的氧合,缩短病程,同时不增加死亡率、并发症,是治疗重症RDS安全、有效的方法。Objective To explore the efficacy and safety of high-frequency oscillatory ventilation （HFOV） in the treatment of severe neonatal respiratory distress syndrome （RDS）. Methods 88 cases of severe neonatal RDS were divided into two groups. 54 cases of research group received HFOV, while 34 cases of control group received conventional mechanical ventilation. The oxygen concentration （FiO2）, arterial oxygen tension （PaOz）, alveolar-arterial oxygen partial pressure ratio （a/APO2）, respiratory index （O1） and disease outcome, complications were observed. Results After treatment, the PaO2 improved in both group. Compared with control group, the research group had lower FiO2, OI and higher a/APO2 at 12 h, 24 h, and 48 h after treatment （all P〈0.05）. The computer time, oxygen therapy time and hospitalization time of research group were shorter than those of control group （P 〈0.05）. There were no statistical differences in the survival rate and incidence of complications between two groups （P 〉0.05）. Conclusions HFOV can effectively improve the oxygenation of severe neonatal RDS, shorten course of disease, and not increase the death rate and complications. It is a safe treatment method for severe neonatal RDS.

关 键 词：高频振荡通气 新生儿 呼吸窘迫综合征 

分 类 号：R725.6[医药卫生—儿科]