硝普钠治疗高血压合并急性左心衰竭的临床研究  

Clinical Research of Sodium Nitroprusside in the Treatment of Acute Left Ventricular Failure Caused by Hypertension

作　　者：林宇彪[1] 林康华[1] 宁观林[1] 

机构地区：[1]广东省吴川市人民医院,广东吴川525400

出　　处：《临床医学工程》2014年第4期441-442,共2页Clinical Medicine & Engineering

摘　　要：目的探讨硝普钠治疗高血压合并急性左心衰竭的临床疗效及安全性。方法 87例高血压合并急性左心衰竭患者,分为治疗组45例和对照组42例,两组均给予常规治疗,在此基础上,治疗组加硝普钠静脉微量泵注射(硝普钠30 mg+0.9%氯化钠注射液47 mL),对照组予硝酸甘油静脉微量泵注射(硝酸甘油30 mg+0.9%氯化钠溶液44 mL)。观察并比较两组的疗效及不良反应。结果治疗组总有效率为97.78%,对照组总有效率为80.95%,两组比较差异有统计学意义(P<0.05)。治疗组有1例发生低血压,对照组有3例发生头痛,经治疗逐渐缓解;两组无其他不良反应。结论硝普钠治疗急性左心衰竭安全有效,无明显低血压及氰化物和硫氰酸盐中毒等不良反应。Objective To investigate the efficacy and safety of sodium nitroprusside in the treatment of acute left ventricular failure caused by hypertension. Methods 87 patients with acute left ventricular failure caused by hypertension were selected and divided into two groups. On the basis of routine therapy, 45 cases of treatment group received intravenous injection of sodium nitroprusside by micropump （30 mg of sodium nitroprusside ＋ 47 mL of 0.9% sodium chloride injection）, while 42 cases of control group received intravenous injection of nitroglycerin by micropump （30 mg of nitroglycerin ＋ 44 mL of 0.9% sodium chloride injection）. The curative effect and adverse reaction were observed and compared between two groups. Results The total effective rate of treatment group was 97.78%, significantly higher than 80.95% of control group, and the difference was statistically significant （P〈0.05）. The treatment group had one case of hypotension, and the control group had 3 cases of headache; all cases gradually eased after treatment. No other adverse reaction was found in both groups. Conclusions Sodium nitroprusside is safe and effective in the treatment of acute left ventricular failure caused by hypertension, without adverse reactions such as obvious hypotension, cyanide or thiocyanate poisoning.

关 键 词：硝普钠 治疗 高血压 急性左心衰竭 

分 类 号：R544.1[医药卫生—心血管疾病]