化学-酶法高选择性合成手性化合物的研究进展  

Recent progress on chemo-enzymatic synthesis of chiral compounds with high stereoselectivity

作　　者：赵淑玲[1] 谷耀华 薛屏[1] 

机构地区：[1]宁夏大学省部共建天然气转化国家重点实验室培育基地,宁夏银川750021

出　　处：《化学研究与应用》2014年第4期473-482,共10页Chemical Research and Application

基　　金：国家自然科学基金项目(21263020)资助;973计划前期研究专项项目(2012CB723106)资助

摘　　要：利用生物酶高反应活性、高区域及立体选择性和催化反应条件温和等优点,酶催化拆分技术已应用于多种重要的手性化合物单一对映体的制备中。化学合成与酶催化联合,二者优势互补,使得手性化合物的制备原料易得、工艺简捷高效且环境友好,获得的手性单一对映体的光学纯度高,因此化学-酶联合催化技术越来越受到人们的关注,不断地被开发并应用于传统化学法不易制备的手性化合物的合成体系中。本文总结和评述了近年来国内外化学-酶催化技术合成醇类、胺类和氨基酸类以及其他手性化合物的研究进展,并对其发展趋势进行了展望。Due to high catalytic activity,regio-and stereo-selectivities and the reactions under mild conditions commonly displayed by enzymes,a variety significant single enantiomers of chiral compounds had been obtained by the technology of enzyme catalysis successfully. Coupling chemical synthesis with enzyme catalysis,the chemo-enzymatic synthesis had shown the complementary ad-vantages,such as large resource for raw materials,straightforward and high efficiency,high optical purity of products and environ-ment friendly,which had gained increased attention. The new systems of chemo-enzymatic synthesis were constantly developed and applied to prepare many chiral building blocks which were difficult to prepare efficiently for traditional chemical synthesis. In this paper,the recent development of chemo-enzymatic synthesis had been shown including preparation of the chiral alcohols,chiral a-mine and amino acids,and other chiral compound respectively. And the focus points for the chemo-enzymatic synthesis in the future had also been demonstrated in the end.

关 键 词：化学-酶法 不对称催化 对映选择性 手性化合物 

分 类 号：O621.34[理学—有机化学]