生育年龄妇女血清胰岛素样生长因子Ⅰ及胰岛素样生长因子结合蛋白1的周期性变化  

Serum Levels of Insulin-Like Growth Factor I and Insulin-Like Growth Factor-Binding Protein-1 in Women with Regular Menstrual Cycles

作　　者：陈丹青[1] 石一复[1] 董明岳[1] 

机构地区：[1]浙江大学医学院附属妇产科医院,浙江杭州310006

出　　处：《浙江大学学报（医学版）》2001年第1期22-24,共3页Journal of Zhejiang University(Medical Sciences)

摘　　要：目的 :探讨胰岛素样生长因子 I( IGF-I)和胰岛素样生长因子结合蛋白 1 ( IGFBP-1 ) ,在正常月经周期妇女体内变化以及和性激素的关系。方法 :分别用 EL ISA法和 RIA法 ,测定 3 4例正常月经周期妇女月经期 (周期第 3 d)、增生晚期 (周期第 1 3 d)、黄体期 (周期第 2 3 d)血清 IGF-I和IGFBP-1 ,以及雌二醇 ( E2 )和孕酮 ( P)浓度。结果 :IGF-I浓度在增生晚期 ( 1 1 4.9± 2 3 .1 ) μg/ L及黄体期 ( 1 2 6.6± 2 7.1 )μg/ L ,显著高于月经期 ( 1 0 4.1± 1 5 .4)μg/ L ,P均 <0 .0 5 ,而增生晚期和黄体期比较差异无显著性 ( P>0 .0 5 )。IGFBP-1浓度在增生晚期 ( 4.5± 1 .8) μg/ L 显著高于黄体期( 2 .3± 0 .9) μg/ L 及月经期 ( 2 .5± 1 .1 ) μg/ L,P均 <0 .0 1 ,而黄体期和月经期比较差异无显著性( P>0 .0 5 )。相关性分析表明 ,增生晚期血清 IGF-I浓度与 E2 有显著相关性 ( r=0 .5 9,P<0 .0 1 )。结论 :血清 IGF-1和Objective:To investigate the cyclic changes of serum insulin like growth factor I(IGF I ) and IGF binding protein 1(IGFBP 1) levels during normal ovulatory menstrual cycle.Me thods :Thirty four young female adults with regular menstural cycles had blood samples obtained at menstural phase,late proliferative and luteal phase.The levels of IGF I and IGFBP 1 were assayed by ELISA.Results:The serum IGF I in the late proliferative phase(114.9±23.1) μg/L and luteal phase(126.6±27.1) μg/L was significantly higher than that in the menstrual phase(104.1±15.4) μg/L( P <0.05).There were no significant difference of serum IGF I between the late proliferative and luteal phase( P >0.05).The serum IGFBP 1 in the late proliferative phase(4.5±1.8) μg/L was significantly higher than that in the menstrual phase(2.5±1.1) μg/L and luteal phase(2.3±0.9) μg/L( P <0.05).There was significantly positive correlation between the levels of E 2 and IGF I in the proliferative phase.Conclusion:The changes of IGF I and IGFBP 1 levels in serum may be related to the menstrual cycle in young female adults.

关 键 词：胰岛素样生长因子Ⅰ IGF-Ⅰ 胰岛素样生长因子结合蛋白1 IGFBP-1 月经周期 

分 类 号：R339.2[医药卫生—人体生理学]