多孔球状淀粉接枝共聚物的应用  

APPLICATION OF POROUS STARCH GRAFT COPOLYMER IN CONTROLLED RELEASS MEDICINE

作　　者：彭湘红[1] 陆茜[1] 李忠铭[1] 王敏绢 

机构地区：[1]华中理工大学汉口分校化工系,武汉430012

出　　处：《精细石油化工》2001年第1期44-46,共3页Speciality Petrochemicals

摘　　要：以反相悬浮法制备的多孔球状淀粉接枝共聚物为载体 ,采用直接压片法制得药物非诺落芬钙的缓释片剂。测定了缓释片剂中非诺落芬钙的体外溶出速率 ,非诺落芬钙在人工肠液中 3 h缓释片剂释放率为3 5%～ 51 % ,全部溶出时间大于 1 2 h,而淀粉与非诺落芬钙压制的淀粉药片中的非诺落芬钙 3 h已全部释放出来。缓释片剂中非诺落芬钙在人工胃液中 4 h释放 3 %～ 1 9% ,随着缓释片剂中多孔球状淀粉接枝共聚物用量增加 ,非诺落芬钙的体外溶出速率也增加。用WT5,5”BZ] The tablets containing fenoprofen calcium(FC) were prepared by directly compressing the mixture of porous starch graft copolymers and drug powders. The effects of the mass ratio of the porous starch graft copolymers to fenoprofen calcium on the release rates of drugs in artificial intestinal and gastric fluids were examined. It was observed that approximately from 35% to 51% of FC release at pH 7.2 within 3 h, 100% of FC release at pH 7.2 over 12 h, about 3% to 19% release of FC was also observed during treated with 1.0 mol/L HCl (pH 1.2) for 4 h. FTIR spectroscopy were used for the confirmation of the graft copolymer and FC, the results indicated that inter molecular hydrogen bond was formed between the porous starch graft copolymers and FC. Release of FC from tablets in vitro indicated that the copolymer is suitable inclusion compound for fenoprofen calcium.

关 键 词：多孔球状淀粉接枝共聚物 药物 非诺落芬钙 缓释片剂 应用 

分 类 号：TQ463.4[化学工程—制药化工]