瑞舒伐他汀逆转颈动脉斑块与急性冠脉综合征介入治疗近期预后的关系  

Correlation between carotid plaques reversal degree due to rosuvastatin therapy and short-term prognosis of the patients with acute coronary syndrome undergoing percutaneous coronary intervention

作　　者：韩冷[1] 倪杰[1] 曹东来[1] 何文兵[1] 何俊[1] 童廉琦[1] 赵品君 王娟[1] 

机构地区：[1]江苏省常熟市第一人民医院心内科,215500

出　　处：《河北医药》2014年第8期1137-1139,共3页Hebei Medical Journal

摘　　要：目的观察急性冠脉综合征（ACS）行经皮冠状动脉介入治疗（PCI）术的患者经瑞舒伐他汀降脂治疗后颈动脉斑块逆转程度与术后主要不良心血管事件（MACE）发生率之间的关系。方法180例急性冠脉综合征患者，予PCI术治疗，术前0—3d开始服用瑞舒伐他汀10mg／d，围术期（手术前后3d内）、术后6个月、12个月分别行颈动脉多普勒超声检查，按照颈动脉粥样斑块减轻的程度分为明显逆转组和无明显逆转组，随访12个月，比较2组患者MACE的发生率。结果明显逆转组患者MACE发生率低于无明显逆转组患者（随访6个月时10．2％VS．22．8％，P〈0．05；随访12个月时17．6％vs43．6％，P〈0．01）。结论瑞舒伐他汀逆转颈动脉斑块程度不一，有明显逆转的ACS患者PCI术后近期预后较好。Objective To observe the effect of rosuvastatin on arteriosclerosis plaque of carotid artery in patients with acute coronary syndrome （ACS） who underwent percutaneous coronary intervention （PCI） and to explore the relationship between carotid plaques reversal degree and the incidence of major adverse cardiac events （MACE） after PCI. Methods A total of 180 patients with ACS （ 109 males and 71 females, age range ： 38 ~ 77yr） were treated with rosuvastatin （ 10mg, 0 - 3 days before and after PCI）. The area of carotid artery plaques was measured by carotid Doppler ultrasound at perioperative period （3 days before and after PCI）, 6 months and 12 months after PCI, then the patients were divided into two groups according to the alleviative degree of carotid atherosclerosis plaques ： group A （ obvious reversal group） and group B （ no obvious reversal group ）, the patients in both groups were followed up for 12 months and the incidences of MACE were compared between the two groups. Results The incidences of MACE in group A were significantly lower than those in group B （ 10.2% vs 22.8% in 6 months after PCI and 17.6% vs 43.6% in 12 months after PCI, P 〈 0.01 ）. Conclusion The rosuvastatin can reverse carotid atherosclerosis plaques at different degrees, the patients with obvious carotid plaques reversal have better short-term prognoses after PCI.

关 键 词：瑞舒伐他汀 颈动脉粥样硬化 冠脉综合征 急性 经皮冠状动脉介入治疗 预后 

分 类 号：R331.371[医药卫生—人体生理学]