65株鲍曼不动杆菌耐药性分析  

Analysis on antibiotic resistance of 65 strains of Acinetobacter baumanii

作　　者：龚燕飞 曾强 刘湘林 张组萍[2] 陈中湘 彭华 

机构地区：[1]岳阳市第一人民医院检验科,湖南岳阳414000 [2]中南大学湘雅医学院

出　　处：《实用预防医学》2014年第4期481-483,共3页Practical Preventive Medicine

基　　金：湖南省科技计划项目(项目编号:2011SK3040)

摘　　要：目的了解鲍曼不动杆菌的临床分布、对常用抗生素的耐药情况,为临床防治提供参考依据。方法对本院收集的65株鲍曼不动杆菌进行细菌培养鉴定及药敏分析。结果亚胺培南耐药鲍曼不动杆菌(IRAB)38株,亚胺培南敏感鲍曼不动杆菌(ISAB)27株,主要来自痰标本。多重耐药(MDR)及泛耐药(PDR)鲍曼不动杆菌菌株分别达53.8%、21.5%,以ICU分布最多。IRAB组耐药率为100%的有亚胺培南、美罗培南、哌拉西林/他唑巴坦、头孢哌酮、头孢西丁、四环素。对头孢哌酮/舒巴坦耐药率最低,为50%。IRAB组与ISAB组除对头孢西丁耐药性较一致外,对其他抗菌药物耐药性差异均有统计学意义(P<0.05)。结论本院鲍曼不动杆菌耐药严重,加强本地区鲍曼不动杆菌耐药性监测,将为指导临床合理用药和医院感染控制提供科学依据。Objective To investigate the clinical distribution of Acinetobacter baumannii and its resistance to antibiotics commonly used so as to provide references for clinical prevention and treatment.Methods Sixty-five strains of Acinetabacter baumannii isolated from the First People＇s Hospital of Yueyang were cultured and identified,and then the drug susceptibility patterns were determined.Results Majority of the strains were isolated from sputum samples,including 38 strains of imipenem-resistant Acinetobacter baumannii （IRAB） and 27 strains of imipenem-sensitive Acinetobacter baumannii （ISAB）.The overall prevalence of multidrug-resistant （MDR） and pandrug-resistant （PDR） Acinetobacter baumannii was 53.8% and 21.5%,respectively,which were mainly isolated from ICU wards.The percentages of the IRAB strains resistant to imipenem,meropenem,piperacillin/tazobactam,cefoperazone,cefoxitin and tetracycline were all 100%,whereas that of the IRAB strains resistant to cefoperazone/sulbactam was the lowest （50%）.The resistance rates to other types of antibiotics in IRAB group were all significantly higher than those in ISAB group except the similar rates to cefoxitin,and the differences were statistically significant （P〈 0.05）.Conclusions Acinetabacter baumannii strains isolated from the hospital were highly resistant to antibiotics.It is necessary to intensify the drug resistance of Acinetobacter baumannii in the local area so as to provide a scientific basis for guiding the rational use of antibiotics and controlling nosocomial infections.

关 键 词：鲍曼不动杆菌 耐药性 抗菌药物 

分 类 号：R378[医药卫生—病原生物学]