新工艺所制备β-磷酸三钙(β-TCP)的生物相容性  

BIOCOMPATIBILITY OFβ-TCP PREPARED BY A NEW TECHNIQUE

作　　者：王丹[1] 胡蕴玉[2] 郑昌琼[3] 谢克难[3] 赵广跃[2] 吕荣[2] 王军[2] 

机构地区：[1]山东济宁医学院附属医院骨科,济宁272129 [2]第四军医大学全军骨科研究所,西安710032 [3]四川大学高新技术学院无机材料系,成都610065

出　　处：《山东生物医学工程》2000年第3期13-18,共6页Shandong Journal of Biomedical Engineering

摘　　要：为了评价新工艺所制备 β -TCP的生物相容性 ,将新工艺所制备 β -TCP进行急性毒性实验、热原实验、溶血实验、小鼠肌袋种植实验和兔桡骨骨缺损修复实验。结果表明β -TCP无毒性、无热原性、不引起溶血反应 ;在小鼠肌肉内和兔骨缺损区植入后可逐渐发生生物降解并被纤维组织和骨组织取代。兔体内植入后血清钙磷离子含量无明显变化。结论　新工艺所制备βTo evaluate the biocompatibility of β-tricalcium phosphate(β-TCP) prepared by a new technique.The experiments on acute toxicity,pyrogen,hemdysis,implantation into muscles in mice and bone defects in rabbits,were carried out.The results of all experiments checking for hemolysis,acute toxicity and pyrogen were found within normal limits.β-TCP could be biodegradated and replaced by fibrous or bone tissues after implantation into muscles in mice or bone defects in rabbits where there were no great changes in contents of calcium and phosphate in serum.β-TCP prepared by a new technique owns excellent biocompatibility.

关 键 词：磷酸钙类 生物相容性 小鼠 兔 

分 类 号：R318.08[医药卫生—生物医学工程]