TSP-1、EGFR、TGF-β1在慢性肺源性心脏病患者血清中的表达  

The serum expression of TSP- 1,EGFR and TGF- beta1 in patients with chronic pulmonary heart disease

作　　者：杨桂兰[1] 杨艳娟[2] 郑西卫[2] 訾瑞[1] 程德云[3] 

机构地区：[1]宁夏医科大学,宁夏银川750004 [2]宁夏医科大学总医院呼吸内科,宁夏银川750004 [3]四川大学华西医院呼吸内科,四川成都610041

出　　处：《宁夏医学杂志》2014年第4期291-293,共3页Ningxia Medical Journal

基　　金：国家自然科学基金资助项目(No30960142)

摘　　要：目的观察凝血酶敏感蛋白1(TSP1)、表皮生长因子受体(EGFR)、转化生长因子β1(TGF-β1)在由慢性阻塞性肺部疾病合并慢性肺源性心脏病患者血清中的表达情况。方法用酶联免疫吸附法检测50例慢性肺源性心脏疾病患者与50例正常对照组血清中TSP-1、EGFR、TGF-β1的表达。结果慢性肺源性心脏病患者血清中TSP-1、EGFR、TGF-β1的表达均明显高于正常对照组(P<0.05)。结论 TSP-1、EGFR、TGF-β1可能参与了由慢性阻塞性肺部疾病发展至慢性肺源性心脏病的病理生理过程。Objective To observe the serum expression of TSP - 1, EGFR and TGF - β1 in patients with chronic pulmonary heart disease. Methods The serum expression of TSP - 1 ,EGFR and TGF - β1 in 50 cases with chronic pulmonary heart disease and 50 nor- real cases were determined by using immunofluorescence test. Results The serum expression of TSP - 1 ,EGFR,and TGF - β1 was higher in chronic pulmonary heart disease group than those in control group （P 〈0.05）. Conclusion TSP- 1 ,EGFR,and TGF- β1 may be involved in the pathophysiologic process of chronic obstructive pulmonary disease developing to chronic pulmonary heart disease.

关 键 词：慢性肺源性心脏疾病 肺动脉高压 慢性阻塞性肺部疾病 凝血酶敏感蛋白1 表皮生长因子受体 转化生长因子β1 

分 类 号：R541.5[医药卫生—心血管疾病]