右美托咪啶在急诊气管插管中的应用  

Applicatiton of dexmedetomidine in emergent intratracheal intubation

作　　者：罗毅[1] 黄振宇[2] 刘路培[1] 毛文雄[1] 黄善华[1] 龙春萍[1] 

机构地区：[1]广西柳州市人民医院急诊科,广西柳州545006 [2]广西柳州市人民医院医务科,广西柳州545006

出　　处：《重庆医学》2014年第11期1326-1328,共3页Chongqing medicine

摘　　要：目的探讨右美托咪啶对急诊科患者气管插管时插管反应的影响。方法选择该院收治的需要紧急行气管插管的成年患者50例,分为右美托咪啶组和咪达唑仑组,每组25例,右美托咪啶组插管前使用右美托咪啶1μg/kg,咪达唑仑组插管前使用咪达唑仑0.1mg/kg。观察两组患者给药前、插管前1min、插管时及插管后1、3、5mim的收缩压(SBP)、血压、心率(HR)和血氧饱和度(SpO2)变化。结果右美托咪啶组患者插管时及插管后1、3min的血压、HR明显低于咪达唑仑组患者(P<0.05)。右美托咪啶组患者插管前1min和插管时SpO2与给药前比较,差异无统计学意义(P>0.05);咪达唑仑组患者插管前1min和插管时SpO2有一定下降,与给药前比较,差异有统计学意义(P<0.05)。结论右美托咪啶比咪达唑仑更有效减轻气管插管时的心血管反应,而对患者呼吸功能几乎无影响。Objective To investigate the effect of dexmedetomidine on the intubation reaction during intratracheal intubation in the patients in the emergency department. Methods Fifty adult patients needing emergent tracheal intubation in the emergency de- partment of this hospital were divided into the dexmedetomidine group and the middazolam group, 25 cases in each group. The dexmedetomidine group was given dexmedetomidine（1μg/kg） before tracheal intubation and the midazolam group was given mid- azolam（0.1 mg/kg） before tracheal intubation. Results BP and HR during tracheal intubation,at 1,3 min after tracheal intubation in the dexmedetomidine group were significantly decreased compared with the midazolam group（P〈0.05） ;SpO2 at 1 min before tracheal intubation and during tracheal intubation in the dexmedetomidine group had no statistical difference compared with before drug administration（P〈0.05）;SPO2 at 1 min before tracheal intubation and during tracheal intubation in the middazolam group was decreased,which showed the statistical difference compared with before drug administration（P〈0.05）. Conclusion Dexme- detomidine is more effective than midazolam in alleviating cardiovascular responses during intratracheal intubation,moreover has no influence on the patientrs respiratory function.

关 键 词：右美托咪啶 急诊室 医院 插管法 气管内 不良反应 

分 类 号：R614[医药卫生—麻醉学]